Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and Acyl Coenzyme A: cholesterol acyltransferase in rats

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dc.contributor.authorS H Lee-
dc.contributor.authorY B Park-
dc.contributor.authorK H Bae-
dc.contributor.authorSong Hae Bok-
dc.contributor.authorY K Kwon-
dc.contributor.authorE S Lee-
dc.contributor.authorM S Choi-
dc.date.accessioned2017-04-19T08:56:23Z-
dc.date.available2017-04-19T08:56:23Z-
dc.date.issued1999-
dc.identifier.issn02506807-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4827-
dc.description.abstractThe effects of dietary supplementation of a citrus bioflavonoid, naringenin, on the cholesterol metabolism were studied. For 42 days male rats were fed a 1% (wt/wt) high-cholesterol diet with or without a naringenin supplementation (0.1%, wt/wt) to study its effect on plasma lipid levels, hepatic lipid contents, activities of hepatic acyl coenzyme A:cholesterol O-acyltransferase (ACAT) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and the excretion of fecal neutral sterols. Naringenin did not significantly alter the concentration of plasma triglycerides, but lowered the plasma cholesterol (3.80 vs. 3.12 mmol/l) concentration and the hepatic cholesterol content (70.3 vs. 54.0 mg/g) significantly (p < 0.05) compared to those of the controls. HMG-CoA reductase (1879.0 vs. 1715.0 pmol/min/mg) and ACAT activities (806.0 vs. 563.0 pmol/min/mg) were significantly lower in the naringenin-supplemented group than in controls. Naringenin supplementation caused a marked decrease in the excretion of fecal neutral sterols (242.9 mg/day) compared to the controls (521.9 mg/ day). These results show that naringenin lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed a high-cholesterol diet.-
dc.publisherKarger-
dc.titleCholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and Acyl Coenzyme A: cholesterol acyltransferase in rats-
dc.title.alternativeCholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and Acyl Coenzyme A: cholesterol acyltransferase in rats-
dc.typeArticle-
dc.citation.titleAnnals of Nutrition and Metabolism-
dc.citation.number0-
dc.citation.endPage180-
dc.citation.startPage173-
dc.citation.volume43-
dc.contributor.alternativeName이성희-
dc.contributor.alternativeName박용복-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName복성해-
dc.contributor.alternativeName권용국-
dc.contributor.alternativeName이은숙-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationAnnals of Nutrition and Metabolism, vol. 43, pp. 173-180-
dc.identifier.doi10.1159/000012783-
dc.subject.keywordHigh-cholesterol diet-
dc.subject.keywordNaringenin-
dc.subject.keyword3-hydroxy-3-methylglutaryl-coenzyme A reductase-
dc.subject.keywordAcyl coenzyme A:cholesterol O-acyltransferase-
dc.subject.keywordLiver cholesterol-
dc.subject.keywordPlasma cholesterol-
dc.subject.localHigh-cholesterol diet-
dc.subject.localNaringenin-
dc.subject.local3-hydroxy-3-methylglutaryl-coenzyme A reductase-
dc.subject.localAcyl coenzyme A:cholesterol O-acyltransferase-
dc.subject.localLiver cholesterol-
dc.subject.localPlasma cholesterol-
dc.description.journalClassY-
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