DC Field | Value | Language |
---|---|---|
dc.contributor.author | S H Lee | - |
dc.contributor.author | Y B Park | - |
dc.contributor.author | K H Bae | - |
dc.contributor.author | Song Hae Bok | - |
dc.contributor.author | Y K Kwon | - |
dc.contributor.author | E S Lee | - |
dc.contributor.author | M S Choi | - |
dc.date.accessioned | 2017-04-19T08:56:23Z | - |
dc.date.available | 2017-04-19T08:56:23Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0250-6807 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4827 | - |
dc.description.abstract | The effects of dietary supplementation of a citrus bioflavonoid, naringenin, on the cholesterol metabolism were studied. For 42 days male rats were fed a 1% (wt/wt) high-cholesterol diet with or without a naringenin supplementation (0.1%, wt/wt) to study its effect on plasma lipid levels, hepatic lipid contents, activities of hepatic acyl coenzyme A:cholesterol O-acyltransferase (ACAT) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and the excretion of fecal neutral sterols. Naringenin did not significantly alter the concentration of plasma triglycerides, but lowered the plasma cholesterol (3.80 vs. 3.12 mmol/l) concentration and the hepatic cholesterol content (70.3 vs. 54.0 mg/g) significantly (p < 0.05) compared to those of the controls. HMG-CoA reductase (1879.0 vs. 1715.0 pmol/min/mg) and ACAT activities (806.0 vs. 563.0 pmol/min/mg) were significantly lower in the naringenin-supplemented group than in controls. Naringenin supplementation caused a marked decrease in the excretion of fecal neutral sterols (242.9 mg/day) compared to the controls (521.9 mg/ day). These results show that naringenin lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed a high-cholesterol diet. | - |
dc.publisher | Karger | - |
dc.title | Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and Acyl Coenzyme A: cholesterol acyltransferase in rats | - |
dc.title.alternative | Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and Acyl Coenzyme A: cholesterol acyltransferase in rats | - |
dc.type | Article | - |
dc.citation.title | Annals of Nutrition and Metabolism | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 180 | - |
dc.citation.startPage | 173 | - |
dc.citation.volume | 43 | - |
dc.contributor.affiliatedAuthor | Song Hae Bok | - |
dc.contributor.affiliatedAuthor | E S Lee | - |
dc.contributor.alternativeName | 이성희 | - |
dc.contributor.alternativeName | 박용복 | - |
dc.contributor.alternativeName | 배기환 | - |
dc.contributor.alternativeName | 복성해 | - |
dc.contributor.alternativeName | 권용국 | - |
dc.contributor.alternativeName | 이은숙 | - |
dc.contributor.alternativeName | 최명숙 | - |
dc.identifier.bibliographicCitation | Annals of Nutrition and Metabolism, vol. 43, pp. 173-180 | - |
dc.identifier.doi | 10.1159/000012783 | - |
dc.subject.keyword | High-cholesterol diet | - |
dc.subject.keyword | Naringenin | - |
dc.subject.keyword | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | - |
dc.subject.keyword | Acyl coenzyme A:cholesterol O-acyltransferase | - |
dc.subject.keyword | Liver cholesterol | - |
dc.subject.keyword | Plasma cholesterol | - |
dc.subject.local | High-Cholesterol Diet | - |
dc.subject.local | High-Cholesterol diet | - |
dc.subject.local | High-cholesterol diet | - |
dc.subject.local | high-cholesterol diet | - |
dc.subject.local | Naringenin | - |
dc.subject.local | naringenin | - |
dc.subject.local | 3-Hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase | - |
dc.subject.local | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | - |
dc.subject.local | Acyl coenzyme A:cholesterol O-acyltransferase | - |
dc.subject.local | Liver cholesterol | - |
dc.subject.local | Plasma cholesterol | - |
dc.description.journalClass | Y | - |
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