α-glucosidase inhibitors from commelina communis

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Title
α-glucosidase inhibitors from commelina communis
Author(s)
Hang Sub Kim; Young Ho Kim; Young Soo Hong; Nam Soo Paek; Hong Sub Lee; Tae Han Kim; Kee Won Kim; Jung Joon Lee
Bibliographic Citation
Planta Medica, vol. 65, pp. 437-439
Publication Year
1999
Abstract
A methanolic extract of Commelina communis showed potent inhibitory activity against α-glucosidase. One pyrrolidine alkaloid, 2,5- dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), α- homonojirimycin (4) and 7-O-β-D-glucopyranosyl α-homonojirimycin (5) were isolated by bioassay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-960803
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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