Pregnane glycoside multidrug-resistance modulators from cynanchum wilfordii

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Title
Pregnane glycoside multidrug-resistance modulators from cynanchum wilfordii
Author(s)
Bang Yeon Hwang; Se Eun Kim; Young Ho Kim; Hang Sub Kim; Young Soo Hong; Jai Seup Ro; Kyong Soon Lee; Jung Joon Lee
Bibliographic Citation
Journal of Natural Products, vol. 62, no. 4, pp. 640-643
Publication Year
1999
Abstract
The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-β-D- cymaropyranosyl(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl- (1→4)-β-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 μM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np980479x
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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