Production of lyophilized culture of Lactobacillus acidophilus with preserving cell viability

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Title
Production of lyophilized culture of Lactobacillus acidophilus with preserving cell viability
Author(s)
Moo Heon Kang; Vibhor Saraswat; Jee Won Lee; Young Hoon Park
Bibliographic Citation
Biotechnology and Bioprocess Engineering, vol. 4, pp. 36-40
Publication Year
1999
Abstract
Optimal lyophilization process was developed for manufacturing the dried product of Lactobacillus acidophilus with high cell viability. Three major factors, freezing rate, specific surface area of samples, and stabilizer type and their synergy were shown to play a crucial role in the development of an effective lyophilization process. Finally we found an optimal combination among three process parameters mentioned above: an exceptionally high cell survival percentage of 90% was achieved using the 8.28 cm-1 specific surface area of samples, slow freezing rate, and a stabilizer composition of 4% skim milk +1% glycerol +0.1% calcium chloride.
Keyword
Lactobacillus acidophiluslyophilizationsurvival percentage
ISSN
1226-8372
Publisher
Springer
DOI
http://dx.doi.org/10.1007/BF02931911
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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