An antibacterial compound against Pasteurella haemolytica produced by Streptomyces sp. = 반추동물 급성기관지폐렴균 Pasteurella haemolytica에 항균활성을 갖는 물질의 특성규명

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Title
An antibacterial compound against Pasteurella haemolytica produced by Streptomyces sp. = 반추동물 급성기관지폐렴균 Pasteurella haemolytica에 항균활성을 갖는 물질의 특성규명
Author(s)
Hee Chol Kang; In Ja Ryoo; Bong Sik Yun; Yong Soo Jeon; Ick Dong Yoo
Bibliographic Citation
Korean Journal of (Applied) Microbiology & Biotechnology, vol. 27, no. 4, pp. 339-343
Publication Year
1999
Abstract
Pasteurella haemolytica is well known to cause severe pneumonia, consolidation and oedema of the lung, and fibrinous pleurisy under the stress and infection of virus in the cattle. In the course of our screening for antimicrobial agents against P. haemolytica, compound 51086 has been isolated from the fermentation broth of Streptomyces sp. 51086. The compound 51086 was purified by SiO2, Sephadex LH-20 and ODS column chromatographies and HPLC, subsequently. The structure of compound 51086 was determined as hygromycin A by combination of 1(H) NMR, 13(C) NMR, HMBC, and ESI-MS. This compound showed significant antibacterial activity against P. haemolytica and P. multocida.
Keyword
hygromycin APasteurella haemolyticastructure determinationantimicrobial activity
ISSN
0257-2389
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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