Effects of IL-18 on expression and function of ICAM-1 in murine natural killer cells = 마우스 NK Cells에서 ICAM-1의 발현과 기능에 대한 IL-18의 효과

Cited 50 time in scopus
Metadata Downloads
Title
Effects of IL-18 on expression and function of ICAM-1 in murine natural killer cells = 마우스 NK Cells에서 ICAM-1의 발현과 기능에 대한 IL-18의 효과
Author(s)
Hyun Keun Song; Dae Ho Cho; Hyung Sik Kang; Yong Man Kim; Kwang Ho Pyun; In Pyo Choi
Bibliographic Citation
Korean Journal of Biological Response Modifiers, vol. 9, no. 2, pp. 269-276
Publication Year
1999
Abstract
The antitumor activity of monoclonal antibodies is mediated by effector cells, such as natural killer (NK) cells, that express Fc receptors for immunoglobulin. Efficacy of monoclonal antibodies, including the CD20 antibody rituximab, could be improved by agents that augment the function of NK cells. Interleukin (IL)-18 is an immunostimulatory cytokine that has antitumor activity in preclinical models. The effects of IL-18 on NK cell function mediated through Fcγ receptors were examined. Human NK cells stimulated with immobilized IgG in vitro secreted IFN-γ as expected; such IFN-γ production was partially inhibited by blocking CD16 with monoclonal antibodies. IL-18 augmented IFN-γ production by NK cells stimulated with immobilized IgG or CD16 antibodies. NK cell IFN-γ production in response to immobilized IgG and/or IL-18 was inhibited by chemical inhibitors of Syk and several other kinases involved in CD16 signaling pathways. IL-18 augmented ADCC of human NK cells against rituximab-coated Raji cells in vitro. IL-18 and rituximab acted synergistically to promote regression of human lymphoma xenografts in SCID mice. Inasmuch as IL-18 costimulates IFN-γ production and ADCC of NK cells activated through Fc receptors in vitro and augments antitumor activity of rituximab in vivo, it is an attractive cytokine to combine with monoclonal antibodies for treatment of human cancer.
Keyword
IL-2IL-18ICAM-1NK cells
ISSN
I000-0010
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.1007/s00262-013-1403-0
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.