Effects of retroviral-mediated Herpes Simplex Virus Thymidine Kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo

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dc.contributor.authorHyun Sang Cho-
dc.contributor.authorYoung Nyun Park-
dc.contributor.authorChuhl Joo Lyu-
dc.contributor.authorChang Hyun Yang-
dc.contributor.authorKi Yang Ryoo-
dc.contributor.authorByung Soo Kim-
dc.contributor.authorKir Young Kim-
dc.contributor.authorYeon Soo Kim-
dc.date.accessioned2017-04-19T08:56:33Z-
dc.date.available2017-04-19T08:56:33Z-
dc.date.issued1999-
dc.identifier.issn0284-186X-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4892-
dc.description.abstractSelective introduction of genes conferring chemosensitivity on proliferating tumor cells can be used to treat cancer. We investigated the efficacy of retrovirus-mediated gene transfer of the herpes simplex virus thymidine kinase (HSV-TK) gene to murine neuroblstoma cell lines [neuro-2a) in vitro and in vivo. Retrovirus-mediated HSV-TK gene transfer to the neuro- 2a cells resulted in sensitivity to ganciclovir (GCV) in vitro. In A/J mice, tumors produced from HSV-TK transduced neuro-2a cells regressed after GCV treatment. Intratumoral injection of recombinant retrovirus expressing HSV-TK gene also inhibited growth of the tumor established in A/J mice. These results demonstrate that HSV-TK gene therapy might be a feasible approach for inhibiting the growth of neuroblastoma.-
dc.publisherT&F (Taylor & Francis)-
dc.titleEffects of retroviral-mediated Herpes Simplex Virus Thymidine Kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo-
dc.title.alternativeEffects of retroviral-mediated Herpes Simplex Virus Thymidine Kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo-
dc.typeArticle-
dc.citation.titleActa Oncologica-
dc.citation.number8-
dc.citation.endPage1097-
dc.citation.startPage1093-
dc.citation.volume38-
dc.contributor.affiliatedAuthorYeon Soo Kim-
dc.contributor.alternativeNameCho-
dc.contributor.alternativeNamePark-
dc.contributor.alternativeNameLyu-
dc.contributor.alternativeNameYang-
dc.contributor.alternativeNameRyoo-
dc.contributor.alternativeNameKim-
dc.contributor.alternativeNameKim-
dc.contributor.alternativeName김연수-
dc.identifier.bibliographicCitationActa Oncologica, vol. 38, no. 8, pp. 1093-1097-
dc.description.journalClassY-
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