5-methylmellein and nectriapyrone, two new monoamine oxidase inhibitors

Cited 0 time in scopus
Metadata Downloads
Title
5-methylmellein and nectriapyrone, two new monoamine oxidase inhibitors
Author(s)
In Kyoung Lee; Bong Sik Yun; Sei Kwan Oh; Young Ho Kim; Myung Koo Lee; Ick Dong Yoo
Bibliographic Citation
Medical Science Research, vol. 27, pp. 463-465
Publication Year
1999
Abstract
In the course of screening for monoamine oxidase (MAO) inhibitors among microbial metabolites, we found that unidentified fungal strain 8082 produced 5-methylmellein, which slows potent inhibitory activity against mouse brain MAO. Although, 5-methylmellein has been previously isolated as a phytotoxin, its MAO inhibitory activity has not hitherto been reported. During the purification of 5-methylmellein, we also isolated nectriapyrone as a minor component. Nectriapyrone has not been previously reported as MAO inhibitor either. We describe the inhibitory activities of 5-methylmellein and nectriapyrone on MAO. 5-Methylmellein and nectriapyrone inhibited MAO in a dose-dependent manner and their IC50 values were 1.06 and 8.9 μM respectively.
Keyword
fungi5-methylmelleinmonoamine oxidase nectriapyronephytotoxin
ISSN
0269-8951
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.