Sine-R.C2 (a homo sapiens specific retroposon) is homologous to CDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp block linked to handedness and psychosis

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dc.contributor.authorH S KIM-
dc.contributor.authorR V Wadekar-
dc.contributor.authorO Takenaka-
dc.contributor.authorC Winstanley-
dc.contributor.authorF Mitsunaga-
dc.contributor.authorT Kageyama-
dc.contributor.authorByung Hwa Hyun-
dc.contributor.authorT J Crow-
dc.date.accessioned2017-04-19T08:56:33Z-
dc.date.available2017-04-19T08:56:33Z-
dc.date.issued1999-
dc.identifier.issn1552-4841-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4894-
dc.description.abstractWe investigated the retroviral/retroposon hypothesis of schizophrenia by generating sequences with PCR primers based on a retroviral sequence recovered by Yee et al. [1998: Schizophr Res 29:92] from a cDNA library from postmortem brain tissue from an individual with psychosis in a genomic region (Xq21.3) that has been tentatively linked to schizophrenia and schizoaffective disorder by Laval et al. [1998: Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:420-427]. Within the block of homology with Yp that was generated by a transposition between the chimpanzee and Homo sapiens we find two sequences, HS307 and HS408, with a high degree of homology to but not identity with the schizophrenic brain cDNA. The closest match of these three sequences is to a family of retroposons, that has evolved from the HERV-K family of endogenous retroviruses, some members of which (e.g., SINE- R.C2) appear to be specific to the human genome. This element has been reported as a cause of Fukuyama-type muscular dystrophy [Kobayashi et al., 1998: Nature 394:388-392]. Such retroposons, as agents of change in the human genome, provide a strategy for investigating pathogenesis. On account of their genomic location in a region that has been subject to change in the course of hominid evolution, and that may have a relationship to psychosis and/or cerebral asymmetry, we conclude that these particular insertions deserve further investigation.-
dc.publisherWiley-
dc.titleSine-R.C2 (a homo sapiens specific retroposon) is homologous to CDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp block linked to handedness and psychosis-
dc.title.alternativeSine-R.C2 (a homo sapiens specific retroposon) is homologous to CDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp block linked to handedness and psychosis-
dc.typeArticle-
dc.citation.titleAmerican Journal of Medical Genetics Part B-Neuropsychiatric Genetics-
dc.citation.number5-
dc.citation.endPage566-
dc.citation.startPage560-
dc.citation.volume88-
dc.contributor.affiliatedAuthorByung Hwa Hyun-
dc.contributor.alternativeName김희수-
dc.contributor.alternativeNameWadekar-
dc.contributor.alternativeNameTakenaka-
dc.contributor.alternativeNameWinstanley-
dc.contributor.alternativeNameMitsunaga-
dc.contributor.alternativeNameKageyama-
dc.contributor.alternativeName현병화-
dc.contributor.alternativeNameCrow-
dc.identifier.bibliographicCitationAmerican Journal of Medical Genetics Part B-Neuropsychiatric Genetics, vol. 88, no. 5, pp. 560-566-
dc.identifier.doi10.1002/(SICI)1096-8628(19991015)88:5<560::AID-AJMG23>3.0.CO;2-W-
dc.subject.keywordretroposon-
dc.subject.keywordSINE-R.C2-
dc.subject.keywordschizophrenia-
dc.subject.keywordXq21.3/Yp block-
dc.subject.keywordprimate-
dc.subject.localRetroposons-
dc.subject.localretroposon-
dc.subject.localSINE-R.C2-
dc.subject.localSchizophrenia-
dc.subject.localschizophrenia-
dc.subject.localXq21.3/Yp block-
dc.subject.localprimate-
dc.subject.localPrimates-
dc.subject.localPrimate-
dc.description.journalClassY-
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