DC Field | Value | Language |
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dc.contributor.author | H S KIM | - |
dc.contributor.author | R V Wadekar | - |
dc.contributor.author | O Takenaka | - |
dc.contributor.author | C Winstanley | - |
dc.contributor.author | F Mitsunaga | - |
dc.contributor.author | T Kageyama | - |
dc.contributor.author | Byung Hwa Hyun | - |
dc.contributor.author | T J Crow | - |
dc.date.accessioned | 2017-04-19T08:56:33Z | - |
dc.date.available | 2017-04-19T08:56:33Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1552-4841 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4894 | - |
dc.description.abstract | We investigated the retroviral/retroposon hypothesis of schizophrenia by generating sequences with PCR primers based on a retroviral sequence recovered by Yee et al. [1998: Schizophr Res 29:92] from a cDNA library from postmortem brain tissue from an individual with psychosis in a genomic region (Xq21.3) that has been tentatively linked to schizophrenia and schizoaffective disorder by Laval et al. [1998: Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:420-427]. Within the block of homology with Yp that was generated by a transposition between the chimpanzee and Homo sapiens we find two sequences, HS307 and HS408, with a high degree of homology to but not identity with the schizophrenic brain cDNA. The closest match of these three sequences is to a family of retroposons, that has evolved from the HERV-K family of endogenous retroviruses, some members of which (e.g., SINE- R.C2) appear to be specific to the human genome. This element has been reported as a cause of Fukuyama-type muscular dystrophy [Kobayashi et al., 1998: Nature 394:388-392]. Such retroposons, as agents of change in the human genome, provide a strategy for investigating pathogenesis. On account of their genomic location in a region that has been subject to change in the course of hominid evolution, and that may have a relationship to psychosis and/or cerebral asymmetry, we conclude that these particular insertions deserve further investigation. | - |
dc.publisher | Wiley | - |
dc.title | Sine-R.C2 (a homo sapiens specific retroposon) is homologous to CDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp block linked to handedness and psychosis | - |
dc.title.alternative | Sine-R.C2 (a homo sapiens specific retroposon) is homologous to CDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp block linked to handedness and psychosis | - |
dc.type | Article | - |
dc.citation.title | American Journal of Medical Genetics Part B-Neuropsychiatric Genetics | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 566 | - |
dc.citation.startPage | 560 | - |
dc.citation.volume | 88 | - |
dc.contributor.affiliatedAuthor | Byung Hwa Hyun | - |
dc.contributor.alternativeName | 김희수 | - |
dc.contributor.alternativeName | Wadekar | - |
dc.contributor.alternativeName | Takenaka | - |
dc.contributor.alternativeName | Winstanley | - |
dc.contributor.alternativeName | Mitsunaga | - |
dc.contributor.alternativeName | Kageyama | - |
dc.contributor.alternativeName | 현병화 | - |
dc.contributor.alternativeName | Crow | - |
dc.identifier.bibliographicCitation | American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, vol. 88, no. 5, pp. 560-566 | - |
dc.identifier.doi | 10.1002/(SICI)1096-8628(19991015)88:5<560::AID-AJMG23>3.0.CO;2-W | - |
dc.subject.keyword | retroposon | - |
dc.subject.keyword | SINE-R.C2 | - |
dc.subject.keyword | schizophrenia | - |
dc.subject.keyword | Xq21.3/Yp block | - |
dc.subject.keyword | primate | - |
dc.subject.local | Retroposons | - |
dc.subject.local | retroposon | - |
dc.subject.local | SINE-R.C2 | - |
dc.subject.local | Schizophrenia | - |
dc.subject.local | schizophrenia | - |
dc.subject.local | Xq21.3/Yp block | - |
dc.subject.local | primate | - |
dc.subject.local | Primates | - |
dc.subject.local | Primate | - |
dc.description.journalClass | Y | - |
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