HIV integrase inhibitory activity of Agastache rugosa
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hye Kyong Kim | - |
| dc.contributor.author | Hyeong Kyu Lee | - |
| dc.contributor.author | Cha Gyun Shin | - |
| dc.contributor.author | Hoon Huh | - |
| dc.date.accessioned | 2017-04-19T08:56:35Z | - |
| dc.date.available | 2017-04-19T08:56:35Z | - |
| dc.date.issued | 1999 | - |
| dc.identifier.issn | 0253-6269 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4909 | - |
| dc.description.abstract | We have been screening anti-HIV integrase compounds from Korean medicinal plants by using an in vitro assay system which is mainly composed of recombinant human immunodeficency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots of Agastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The IC50 of the rosmarinic acid was approximately 10 μg/ml against HIV integrase. | - |
| dc.publisher | Pharmaceutical Soc Korea | - |
| dc.title | HIV integrase inhibitory activity of Agastache rugosa | - |
| dc.title.alternative | HIV integrase inhibitory activity of Agastache rugosa | - |
| dc.type | Article | - |
| dc.citation.title | Archives of Pharmacal Research | - |
| dc.citation.number | 5 | - |
| dc.citation.endPage | 523 | - |
| dc.citation.startPage | 520 | - |
| dc.citation.volume | 22 | - |
| dc.contributor.affiliatedAuthor | Hyeong Kyu Lee | - |
| dc.contributor.alternativeName | 김혜경 | - |
| dc.contributor.alternativeName | 이형규 | - |
| dc.contributor.alternativeName | 신차균 | - |
| dc.contributor.alternativeName | 허훈 | - |
| dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 22, no. 5, pp. 520-523 | - |
| dc.identifier.doi | 10.1007/BF02979163 | - |
| dc.subject.keyword | HIV integrase | - |
| dc.subject.keyword | Agastache rugosa | - |
| dc.subject.keyword | Labiatae | - |
| dc.subject.keyword | Rosmarinic acid | - |
| dc.subject.local | HIV integrase | - |
| dc.subject.local | Agastache rugosa | - |
| dc.subject.local | agastache rugosa | - |
| dc.subject.local | Labiatae | - |
| dc.subject.local | labiatae | - |
| dc.subject.local | Rosmarinic acid | - |
| dc.subject.local | rosmarinic acid | - |
| dc.description.journalClass | Y | - |
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