Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages

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dc.contributor.authorB Y Kang-
dc.contributor.authorY J Song-
dc.contributor.authorK Kim-
dc.contributor.authorYong Kyung Choe-
dc.contributor.authorS Y Hwang-
dc.contributor.authorT S Kim-
dc.date.accessioned2017-04-19T08:56:39Z-
dc.date.available2017-04-19T08:56:39Z-
dc.date.issued1999-
dc.identifier.issn0007-1188-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/4929-
dc.description.abstract1. Interleukin-12 (IL-12) plays a central role in the immune system by driving the immune response towards T helper 1 (Th1) type responses which are characterized by high IFN-γ and low IL-4 production. In this study we investigated the effects of curcumin, a natural product of plants obtained from Curcuma longa (turmeric), on IL-12 production by mouse splenic macrophages and the subsequent ability of these cells to regulate cytokine production by CD4+ T cells. 2. Pretreatment with curcumin significantly inhibited IL-12 production by macrophages stimulated with either lipopolysaccharide (LPS) or head-killed Listeria monocytogenes (HKL). 3. Curcumin-pretreated macrophages reduced their ability to induce IFN-γ and increased the ability to induce IL-4 in Ag-primed CD4+ T cells. Addition of recombinant IL-12 to cultures of curcumin-pretreated macrophages and CD4+ T cells restored IFN-γ production in CD4+ T cells. 4. The in vivo administration of curcumin resulted in the inhibition of IL-12 production by macrophages stimulated in vitro with either LPS or HKL, leading to the inhibition of Th1 cytokine profile (decreased IFN-γ and increased IL-4 production) in CD4+ T cells. 5. These findings suggest that curcumin may inhibit Th1 cytokine profile in CD4+ T cells by suppressing IL-12 production in macrophages, and points to a possible therapeutic use of curcumin in the Th1-mediated immune diseases.-
dc.publisherWiley-
dc.titleCurcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages-
dc.title.alternativeCurcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages-
dc.typeArticle-
dc.citation.titleBritish Journal of Pharmacology-
dc.citation.number2-
dc.citation.endPage384-
dc.citation.startPage380-
dc.citation.volume128-
dc.contributor.affiliatedAuthorYong Kyung Choe-
dc.contributor.alternativeNameKang-
dc.contributor.alternativeNameSong-
dc.contributor.alternativeNameKim-
dc.contributor.alternativeName최용경-
dc.contributor.alternativeNameHwang-
dc.contributor.alternativeNameKim-
dc.identifier.bibliographicCitationBritish Journal of Pharmacology, vol. 128, no. 2, pp. 380-384-
dc.identifier.doi10.1038/sj.bjp.0702803-
dc.subject.keywordCurcumin-
dc.subject.keywordinterleukin-12-
dc.subject.keywordmacrophage-
dc.subject.keywordT helper cell-
dc.subject.keywordcytokine profile-
dc.subject.localCurcumin-
dc.subject.localcurcumin-
dc.subject.localInterleukin-12-
dc.subject.localinterleukin-12-
dc.subject.localmacrophage-
dc.subject.localmacrophages-
dc.subject.localMacrophage-
dc.subject.localMacrophages-
dc.subject.localT helper cell-
dc.subject.localT helper cells-
dc.subject.localcytokine profile-
dc.description.journalClassY-
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