DC Field | Value | Language |
---|---|---|
dc.contributor.author | B Y Kang | - |
dc.contributor.author | Y J Song | - |
dc.contributor.author | K Kim | - |
dc.contributor.author | Yong Kyung Choe | - |
dc.contributor.author | S Y Hwang | - |
dc.contributor.author | T S Kim | - |
dc.date.accessioned | 2017-04-19T08:56:39Z | - |
dc.date.available | 2017-04-19T08:56:39Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/4929 | - |
dc.description.abstract | 1. Interleukin-12 (IL-12) plays a central role in the immune system by driving the immune response towards T helper 1 (Th1) type responses which are characterized by high IFN-γ and low IL-4 production. In this study we investigated the effects of curcumin, a natural product of plants obtained from Curcuma longa (turmeric), on IL-12 production by mouse splenic macrophages and the subsequent ability of these cells to regulate cytokine production by CD4+ T cells. 2. Pretreatment with curcumin significantly inhibited IL-12 production by macrophages stimulated with either lipopolysaccharide (LPS) or head-killed Listeria monocytogenes (HKL). 3. Curcumin-pretreated macrophages reduced their ability to induce IFN-γ and increased the ability to induce IL-4 in Ag-primed CD4+ T cells. Addition of recombinant IL-12 to cultures of curcumin-pretreated macrophages and CD4+ T cells restored IFN-γ production in CD4+ T cells. 4. The in vivo administration of curcumin resulted in the inhibition of IL-12 production by macrophages stimulated in vitro with either LPS or HKL, leading to the inhibition of Th1 cytokine profile (decreased IFN-γ and increased IL-4 production) in CD4+ T cells. 5. These findings suggest that curcumin may inhibit Th1 cytokine profile in CD4+ T cells by suppressing IL-12 production in macrophages, and points to a possible therapeutic use of curcumin in the Th1-mediated immune diseases. | - |
dc.publisher | Wiley | - |
dc.title | Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages | - |
dc.title.alternative | Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages | - |
dc.type | Article | - |
dc.citation.title | British Journal of Pharmacology | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 384 | - |
dc.citation.startPage | 380 | - |
dc.citation.volume | 128 | - |
dc.contributor.affiliatedAuthor | Yong Kyung Choe | - |
dc.contributor.alternativeName | Kang | - |
dc.contributor.alternativeName | Song | - |
dc.contributor.alternativeName | Kim | - |
dc.contributor.alternativeName | 최용경 | - |
dc.contributor.alternativeName | Hwang | - |
dc.contributor.alternativeName | Kim | - |
dc.identifier.bibliographicCitation | British Journal of Pharmacology, vol. 128, no. 2, pp. 380-384 | - |
dc.identifier.doi | 10.1038/sj.bjp.0702803 | - |
dc.subject.keyword | Curcumin | - |
dc.subject.keyword | interleukin-12 | - |
dc.subject.keyword | macrophage | - |
dc.subject.keyword | T helper cell | - |
dc.subject.keyword | cytokine profile | - |
dc.subject.local | Curcumin | - |
dc.subject.local | curcumin | - |
dc.subject.local | Interleukin-12 | - |
dc.subject.local | interleukin-12 | - |
dc.subject.local | macrophage | - |
dc.subject.local | macrophages | - |
dc.subject.local | Macrophage | - |
dc.subject.local | Macrophages | - |
dc.subject.local | T helper cell | - |
dc.subject.local | T helper cells | - |
dc.subject.local | cytokine profile | - |
dc.description.journalClass | Y | - |
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