Gene expression of neuroD/BETA2 during development of the mouse central nervous system = 생쥐 중추신경계에서 NeuroD/BETA2 유전자의 발현

Abstract

NeuroD/BETA2, a basic helix-loop-helix transcription factor, has been known to play a role in terminal differentiation during neurogenesis. To gain further insight into the function of NeuroD/BETA2 in the nervous system development, we examined the expression pattern of NeuroD/BETA2 during embryonic and postnatal development by in situ hybridization. Dynamic changes of NeuroD/BETA2 expression were observed in the developing nervous system. Gene expression of the NeuroD/BETA2 in developing cerebellum and hippocampus increased during the embryonic stages and persisted throughout postnatal development and remained at a stable level in the adult brain. NeuroD/BETA2 expression was detected in postmitotic cells in the subventricular zone of the cerebrum during embryogenesis. This observation confirms that NeuroD/BETA2 may have a role in terminal differentiation during neurogenesis.