Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii

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Title
Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii
Author(s)
Bong Sik Yun; In Kyoung Lee; Jong Pyung Kim; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 53, no. 2, pp. 114-122
Publication Year
2000
Abstract
In our continuous investigation for free radical scavengers from extracts of fruit body of basidiomycetes, we have isolated four new p-terphenyl compounds, designated as curtisians A~D, from the methanolic extract of the fruit body of Paxillus curtisii. These compounds were isolated by silica gel and Sephadex LH-20 column chromatographies, preparative-TLC and HPLC, consecutively. The structures of curtisians were assigned as p-terphanyls with substituents of acetyl, benzoyl, phenylbutyryl, 3-hydroxybutyryl and 3-acetoxybutyryl. Curtisians A, B, C and D exhibited inhibitory activity against lipid peroxidation with IC50 values of 0.15, 0.17, 0.24 and 0.14 μg/ml, respectively.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.53.114
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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