Isolation of cDNA clones encoding human histone macroH2A1 subtypes

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Title
Isolation of cDNA clones encoding human histone macroH2A1 subtypes
Author(s)
Yong Hee Lee; Mi Hui Hong; Jae Wha Kim; Yun Mi Hong; Yong Kyung Choe; Sung Yeoul Chang; Kwang Soo Lee; In Seong Choe
Bibliographic Citation
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol. 1399, no. 1, pp. 73-77
Publication Year
1998
Abstract
cDNA clones encoding two different subtypes of histone macroH2A1, macroH2A1.1 and macroH2A1.2, have been isolated from human liver tissue. The open reading frames in the isolated clones predicted proteins comprising 368 and 371 amino acids respectively. Estimated molecular masses of the two proteins were 39.0 kDa and 39.4 kDa. Human histone macroH2A1.1 and macroH2A1.2 showed about 98% identity with their counterparts isolated from rat. The features of the nucleotide sequences of the two macroH2A1 subtypes in human were the same as in the rat system. Northern blot analysis showed that the macroH2A1.1 and macroH2A1.2 subtypes were expressed as mRNA species with a size of 1.5 and 4.4 kb, respectively. They were expressed in all human tissues examined.
Keyword
macroH2A1 subtypecDNA sequencetissue distribution(Human)
ISSN
1874-9399
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0167-4781(98)00098-0
Type
Article
Appears in Collections:
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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