Development of new adherent mutant from human myelomaderived cell line: in vitro model of anaplastic transformation of myeloma

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorKyung Cheon Jung-
dc.contributor.authorChan Sik Park-
dc.contributor.authorHae Won Sohn-
dc.contributor.authorMyeong Cherl Kook-
dc.contributor.authorDo Hyun Chung-
dc.contributor.authorYang Kyu Choi-
dc.contributor.authorByung Hwa Hyun-
dc.contributor.authorIm Soon Lee-
dc.contributor.authorYoung Mee Bae-
dc.contributor.authorHyung Geun Song-
dc.contributor.authorSeong Hoe Park-
dc.date.accessioned2017-04-19T08:56:55Z-
dc.date.available2017-04-19T08:56:55Z-
dc.date.issued1999-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5029-
dc.description.abstractAnaplastic myeloma is a rare but distinct, biologically aggressive variant of myeloma which usually results from dedifferentiation or anaplastic transformation of the myeloma cells. The molecular mechanisms that determine the biologic behavior of anaplastic myeloma and effective treatment modalities have not been well known due to lack of in vitro models. In the present study, we have developed an anaplastically transformed mutant from a human myeloma-derived cell line. In the process of long-term culture of the myeloma-derived IM-9 cell line in low serum and nutrient conditions, an adherent mutant line was developed and named IM-9/ AD. This mutant cell line displayed several characteristics resembling anaplastic myeloma such as: 1, large cells with large vesicular nucleus and prominent nucleolus, multinuclearity and high mitotic figures; 2, loss of leukocyte-associated antigens; and 3, higher tumorigenecity in scid mice than its parental cell line. This newly developed mutant cell line may serve as a readily available in vitro model to investigate the biology of anaplastic myeloma.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleDevelopment of new adherent mutant from human myelomaderived cell line: in vitro model of anaplastic transformation of myeloma-
dc.title.alternativeDevelopment of new adherent mutant from human myelomaderived cell line: in vitro model of anaplastic transformation of myeloma-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number6-
dc.citation.endPage661-
dc.citation.startPage657-
dc.citation.volume9-
dc.contributor.affiliatedAuthorYang Kyu Choi-
dc.contributor.affiliatedAuthorByung Hwa Hyun-
dc.contributor.alternativeName정경천-
dc.contributor.alternativeName박찬식-
dc.contributor.alternativeName손해원-
dc.contributor.alternativeName국명철-
dc.contributor.alternativeName정도현-
dc.contributor.alternativeName최양규-
dc.contributor.alternativeName현병화-
dc.contributor.alternativeName이임순-
dc.contributor.alternativeName배영미-
dc.contributor.alternativeName송형근-
dc.contributor.alternativeName박성회-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 9, no. 6, pp. 657-661-
dc.subject.keywordanaplastic myeloma-
dc.subject.keywordIM-9/AD-
dc.subject.keywordin vitro model-
dc.subject.localanaplastic myeloma-
dc.subject.localIM-9/AD-
dc.subject.localin vitro model-
dc.subject.localIn vitro model-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.