Screening of microorganisms producing esterase for the production of (R)-β-acetylmercaptoisobutyric acid from methyl (R,S)-β-acetylmercaptoisobutyrate

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dc.contributor.authorBoyapati Gokul-
dc.contributor.authorJe Hyuk Lee-
dc.contributor.authorKi Bang Song-
dc.contributor.authorT Panda-
dc.contributor.authorSang Ki Rhee-
dc.contributor.authorChul Ho Kim-
dc.date.accessioned2017-04-19T08:56:55Z-
dc.date.available2017-04-19T08:56:55Z-
dc.date.issued2000-
dc.identifier.issn1226-8372-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5030-
dc.description.abstract(R)-β-acetylmercaptoisobutyric acid (RAM), a chiral compound, is an important intermediate for the chemical synthesis of various antihypertensive and congestive heart failure drugs. Microorganisms capable of converting (R,S)-β-acetylmercaptoisobutyric acid ((R,S)-ester) to RAM were screened from soil microorganisms. A strain of Pseudomonas sp. 1001 screened from a soil sample was selected to be the best. Cells showed an activity of 540 U/mL from culture broth and the enzyme was thermostable up to 70°C. This strain could produce RAM asymmetrically from (R,S)-ester.-
dc.publisherSpringer-
dc.titleScreening of microorganisms producing esterase for the production of (R)-β-acetylmercaptoisobutyric acid from methyl (R,S)-β-acetylmercaptoisobutyrate-
dc.title.alternativeScreening of microorganisms producing esterase for the production of (R)-β-acetylmercaptoisobutyric acid from methyl (R,S)-β-acetylmercaptoisobutyrate-
dc.typeArticle-
dc.citation.titleBiotechnology and Bioprocess Engineering-
dc.citation.number1-
dc.citation.endPage60-
dc.citation.startPage57-
dc.citation.volume5-
dc.contributor.affiliatedAuthorJe Hyuk Lee-
dc.contributor.affiliatedAuthorKi Bang Song-
dc.contributor.affiliatedAuthorSang Ki Rhee-
dc.contributor.affiliatedAuthorChul Ho Kim-
dc.contributor.alternativeNameGokul-
dc.contributor.alternativeName이제혁-
dc.contributor.alternativeName송기방-
dc.contributor.alternativeNamePanda-
dc.contributor.alternativeName이상기-
dc.contributor.alternativeName김철호-
dc.identifier.bibliographicCitationBiotechnology and Bioprocess Engineering, vol. 5, no. 1, pp. 57-60-
dc.identifier.doi10.1007/BF02932355-
dc.subject.keyword(R)-β-acetylmercaptoisobutyric acid-
dc.subject.keywordPseudomonas sp.-
dc.subject.keywordesterase-
dc.subject.keywordenzymatic resolution-
dc.subject.local(R)-β-acetylmercaptoisobutyric acid-
dc.subject.localPseudomonas sp.-
dc.subject.localpseudomonas sp.-
dc.subject.localEsterase-
dc.subject.localesterases-
dc.subject.localesterase-
dc.subject.localenzymatic resolution-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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