Antimicrobial activity of 9-O-Acyl- and 9-O-Benzoyl-substituted berberrubines

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Title
Antimicrobial activity of 9-O-Acyl- and 9-O-Benzoyl-substituted berberrubines
Author(s)
Sung Han Kim; Jung Ae Jeun; Sang Jun Lee; Sung Uk Kim; Jung Han Kim
Bibliographic Citation
Planta Medica, vol. 66, no. 4, pp. 361-363
Publication Year
2000
Abstract
In the course of a structure-activity relationship study on berberrubine derivatives, a series of compounds bearing 9-O-acyl- (4-6) and 9-O-benzoyl- (7) substituents was synthesized with the expectation of increasing the antimicrobial activity. One of the berberrubine derivatives, 9- lauroylberberrubine chloride was the most active against Gram-positive bacteria Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis as well as the Gram- negative bacterium Klebsiella pneumoniae in comparison to berberine, the currently used antibiotic in clinic. This result suggested that the presence of lipophilic substituents of certain structures and sizes might be crucial for the optimal antimicrobial activity.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2000-8536
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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