Sesquiterpene lactones, inhibitors of farnesyl protein transferase, isolated from the flower of Artemisia sylvatica

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Title
Sesquiterpene lactones, inhibitors of farnesyl protein transferase, isolated from the flower of Artemisia sylvatica
Author(s)
Seung Ho lee; Hyun Mi Kang; Ho Chul Song; Hee Soon Lee; Un Chul Lee; Kwang Hee Son; Sung Hoon Kim; Byoung-Mog Kwon
Bibliographic Citation
Tetrahedron, vol. 56, no. 27, pp. 4711-4715
Publication Year
2000
Abstract
Five sesquiterpene lactones, 8-acetylarteminolide (1), artanomaloide (2), arteminones (3 and 4), and dehydromatricarin (5), were isolated from the methanolic extract of the flower of Artemisia sylvatica and characterized on the basis of their spectral data. New sesquiterpene lactone 1 was identified as a configurational isomer of artanomaloide (2), and the new arteminones 3 and 4 are determined as stereoisomers. 8-Acetylarteminolide (1) strongly inhibited FPTase with an IC50 of 1.8 μM, however, the other sesquiterpene lactones mildly inhibited the transferase with an IC50 of 22-300 μM.
Keyword
artemisia sylvaticafarnesyl proteinsesquiterpene lactones
ISSN
0040-4020
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0040-4020(00)00394-X
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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