Chaetoatrosin A, a novel chitin synthase II inhibitor produced by Chaetomium atrobrunneum F449

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Title
Chaetoatrosin A, a novel chitin synthase II inhibitor produced by Chaetomium atrobrunneum F449
Author(s)
Eui Il Hwang; Bong Sik Yun; Young Kook Kim; Byoung-Mog Kwon; Hong Gi Kim; Hyang Bok Lee; Kyung Sook Bae; Sung Uk Kim
Bibliographic Citation
Journal of Antibiotics, vol. 53, no. 3, pp. 248-255
Publication Year
2000
Abstract
Chaetoatrosin A, a novel chitin synthase II inhibitor, was isolated from the culture broth of fungus F449, which was identified as Chaetomium atrobrunneum F449. Chaetoatrosin A was purified by solvent partition, silica gel, ODS, preparative TLC, and Sephadex LH-20 column chromatographies, consecutively. The structure of chaetoatrosin A was assigned as 1,8-dihydroxy-3(2-hydroxypropionyl)-6-methoxynaphthalene on the basis of various spectroscopic analyses including UV, IR, mass spectral, and NMR. Its molecular weight and formula were found to be 262 and C14H14O5, respectively. Chaetoatrosin A inhibited chitin synthase II by 50% at the concentration of 104 μg/ml in an enzyme assay system. This compound showed antifungal activities against Rhizoctonia solani, Pyricularia oryzae, Botrytis cinerea, Cryptococcus neoformans and Trichophyton mentagrophytes.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.53.248
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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