Chaetoatrosin A, a novel chitin synthase II inhibitor produced by Chaetomium atrobrunneum F449
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- Title
- Chaetoatrosin A, a novel chitin synthase II inhibitor produced by Chaetomium atrobrunneum F449
- Author(s)
- Eui Il Hwang; Bong Sik Yun; Young Kook Kim; Byoung-Mog Kwon; Hong Gi Kim; Hyang Bok Lee; Kyung Sook Bae; Sung Uk Kim
- Bibliographic Citation
- Journal of Antibiotics, vol. 53, no. 3, pp. 248-255
- Publication Year
- 2000
- Abstract
- Chaetoatrosin A, a novel chitin synthase II inhibitor, was isolated from the culture broth of fungus F449, which was identified as Chaetomium atrobrunneum F449. Chaetoatrosin A was purified by solvent partition, silica gel, ODS, preparative TLC, and Sephadex LH-20 column chromatographies, consecutively. The structure of chaetoatrosin A was assigned as 1,8-dihydroxy-3(2-hydroxypropionyl)-6-methoxynaphthalene on the basis of various spectroscopic analyses including UV, IR, mass spectral, and NMR. Its molecular weight and formula were found to be 262 and C14H14O5, respectively. Chaetoatrosin A inhibited chitin synthase II by 50% at the concentration of 104 μg/ml in an enzyme assay system. This compound showed antifungal activities against Rhizoctonia solani, Pyricularia oryzae, Botrytis cinerea, Cryptococcus neoformans and Trichophyton mentagrophytes.
- ISSN
- 0021-8820
- Publisher
- Springer-Nature Pub Group
- DOI
- http://dx.doi.org/10.7164/antibiotics.53.248
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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