Two p-terphenyls from mushroom Paxillus panuoides with free radical scavenging activity

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Title
Two p-terphenyls from mushroom Paxillus panuoides with free radical scavenging activity
Author(s)
Bong Sik Yun; In Kyoung Lee; Jong Pyung Kim; Ick Dong Yoo
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 10, no. 2, pp. 233-237
Publication Year
2000
Abstract
As part of a continuing investigation to identify free radical scavengers from the fruit bodies of basidiomycetes, we isolated two p- terphenyl compounds, designated as PA1 and PA21, from methanolic extract of the fruit body of Paxillus panuoides. The methanolic extract was processed by ethyl acetate extraction and silica gel column chromatography to yield two active fractions. PA1 was obtained from one of the fractions through Sephadex LH-20 and silica gel column chromatographies and reverse-phase HPLC. The other fraction was purified by Sephadex LH-20 and reverse-phase column chromatographies to produce PA2. The compounds PA1 and PA2 were identified as leucomentin-4 and leucomentin-2, respectively, on the basis of various spectroscopic analyses. These compounds exhibited strong inhibitory activities against lipid peroxidation in rat liver microsomes with IC50 values of 0.10 and 0.06 μg/ml, respectively.
Keyword
Paxillus panuoidesleucomentinslipid peroxidation inhibitorchemical structure
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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