Analytical techniques for vancomycin - A review

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Title
Analytical techniques for vancomycin - A review
Author(s)
Avinash P Sattur; Je Hyuk Lee; Ki Bang Song; T Panda; Chul Ho Kim; Sang Ki Rhee; B Gokul
Bibliographic Citation
Biotechnology and Bioprocess Engineering, vol. 5, no. 3, pp. 153-158
Publication Year
2000
Abstract
Vancomycin belongs to the vancomycin-ristocetin family of glycopeptides, and is a subclass of linear sugar containing peptides composed of seven amino acids. Its stereochemical configuration forms the basis of a particular mode of action, though its complexation with the D-alanyl-D-alanine terminus of peptidoglycon monomer. The glycosylated hexapeptide chain consists of chloro-β-hydroxytyrosines, p-hydroxyphenylglycines, N-methylleucine and aspartic acid forms a rigid molecular frame work and gives the difficulty in the analysis. Vancomycin in the serum samples is usually estimated by liquid chromatography and the bacterial sensitivity was genereally tested by the microbiological assay. The present review deals with the qualitative, quantitative, microbiological and immunological assays and the comparison of the quantitative methods. Clinical implications of vancomycin have also been cited in the review.
Keyword
vancomycindalbaheptapeptidesamylocolaptosis orientalisglycopeptideanalytical methods
ISSN
1226-8372
Publisher
South Korea
DOI
http://dx.doi.org/10.1007/BF02936586
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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