Antiphotooxidative activity of protoberberines derived from coptis japonica makino in the chlorophyll-sensitized photooxidation of oil

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dc.contributor.authorJin Pyo Kim-
dc.contributor.authorMun Yhung Jung-
dc.contributor.authorJong Pyung Kim-
dc.contributor.authorSung Yeol Kim-
dc.date.accessioned2017-04-19T08:57:01Z-
dc.date.available2017-04-19T08:57:01Z-
dc.date.issued2000-
dc.identifier.issn00218561-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5073-
dc.description.abstractAntiphotooxidative components were isolated from the methanolic extract of Coptis japonica Makino by liquid-liquid partitioning fractionation, subsequent column chromatography on Sephadex LH20 and silica gel, and preparative silica gel TLC. The isolated compounds were identified as coptisine, jatrorrizhine, berberine, and magnoflorine by a combination of spectroscopic studies using UV-visible, IR, mass-spectrometry, and NMR. Coptisine, jatrorrizhine, and berberine isolated from Coptis japonica Makino showed strong antiphotooxidative activity in the chlorophyll-sensitized photooxidation of linoleic acid. However, these compounds did not show either inhibitory activity against lipid peroxidation in rat liver microsomes nor DPPH radical scavenging activity, indicating that their antiphotooxidative activity was not due to the radical chain reaction breaking ability but due to singlet oxygen quenching activity. Commercially available authentic protoberberines (berberine chloride and palmatine chloride) also showed strong antioxidative activity in the chlorophyllsensitized photooxidation of linoleic acid. The antiphotooxidative activities of the berberine chloride and palmatine chloride were significantly higher than that of ascorbyl palmitate in the chlorophyllsensitized photooxidation of linoleic acid. These results clearly showed for the first time the antiphotooxidative properties of protoberberines in chlorophyll-sensitized photooxidation of oil.-
dc.publisherAmer Chem Soc-
dc.titleAntiphotooxidative activity of protoberberines derived from coptis japonica makino in the chlorophyll-sensitized photooxidation of oil-
dc.title.alternativeAntiphotooxidative activity of protoberberines derived from coptis japonica makino in the chlorophyll-sensitized photooxidation of oil-
dc.typeArticle-
dc.citation.titleJournal of Agricultural and Food Chemistry-
dc.citation.number4-
dc.citation.endPage1063-
dc.citation.startPage1058-
dc.citation.volume48-
dc.contributor.affiliatedAuthorJong Pyung Kim-
dc.contributor.alternativeName김진표-
dc.contributor.alternativeName정문영-
dc.contributor.alternativeName김종평-
dc.contributor.alternativeName김성열-
dc.identifier.bibliographicCitationJournal of Agricultural and Food Chemistry, vol. 48, no. 4, pp. 1058-1063-
dc.identifier.doi10.1021/jf9909297-
dc.subject.keywordCoptis japonica Makino-
dc.subject.keywordphotooxidation-
dc.subject.keywordberberine-
dc.subject.keywordcoptisine-
dc.subject.keywordjatrorrizhine-
dc.subject.keywordmagnoflorine-
dc.subject.keywordchlorophylls-
dc.subject.keywordsinglet oxygen-
dc.subject.localCoptis japonica Makino-
dc.subject.localphotooxidation-
dc.subject.localberberine-
dc.subject.localBerberine-
dc.subject.localcoptisine-
dc.subject.localjatrorrizhine-
dc.subject.localmagnoflorine-
dc.subject.localchlorophylls-
dc.subject.localsinglet oxygen-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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