Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats

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Title
Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol fed rats
Author(s)
Song Hae Bok; Yong Won Shin; Ki Hwan Bae; Tae Sook Jeong; Yong Kook Kwon; Yong Bok Park; Myung Sook Choi
Bibliographic Citation
Nutrition Research, vol. 20, no. 7, pp. 1007-1015
Publication Year
2000
Abstract
The effects of naringin on lipid metabolism were examined in rats that were fed a high, fat (15 g lard/100 g) and high-cholesterol (1 g/100 g) diet. Low- or high-doses (0.02 g or 0.05 g/100 g) of either naringin or lovastatin were supplemented in an experimental diet for 35 d. The concentrations of plasma total cholesterol were significantly lower in the naringin- and lovastatin-supplemented groups than in the control group fed a basal diet. In addition, both doses of lovastatin and a high-dose naringin significantly lowered plasma triglyceride concentrations compared to the control group. All naringin and lovastatin supplements, except for the high-dose lovastatin, significantly lowered the hepatic cholesterol concentration compared to the control group. The concentrations of hepatic triglyceride in the naringin- supplemented groups (0.34±0.06 mmol/g and 0.30±0.06 mmol/g) and control (0.33±0.06 mmol/g) were significantly lower than in the lovastatin- supplemented groups (0.40±0.03 mmol/g and 0.42±0.05 mmol/g). High and low doses of naringin significantly lowered the activities of 3-hydroxy-3-methyl- glutaryl-coenzyme A (HMG-CoA) reductase by 54% and 39%, respectively, compared to the control group, while lovastatin did not demonstrate any inhibitory activity on this enzyme. The activities of acyl coenzyme A:cholesterol O-acyltransferase (ACAT) were significantly lower in all experimental groups than in the control. Accordingly, lipid-lowering action of naringin seems to be different from that of lovastatin in a high-fat and high-cholesterol fed rats.
Keyword
cholesteroltriglyceridenaringinlovastatinHMG-CoA reductaseACAT
ISSN
0271-5317
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0271-5317(00)00191-3
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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