Phylogenetic analysis of HERV-K LTR family in human chromosome Xq26 and new world monkeys

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Phylogenetic analysis of HERV-K LTR family in human chromosome Xq26 and new world monkeys
Heui Soo Kim; Joo Young Choi; Won Ho Lee; Kyung Lib Jang; Won Hyuck Park; Doo Ho Moon; Osamu Takenaka; Byung Hwa Hyun
Bibliographic Citation
Korean Journal of Life Sciences, vol. 10, no. 1, pp. 32-36
Publication Year
Solitary long terminal repeats(LTRs) of human endogenous retrovirus K family(HERV-K) have been found to be coexpressed with sequences of closely located genes. It has been suggested that HERV-K LTR-like elements entered the primate genome approximately 33-40 million years ago. WE investigated the presence of HERV-K LTR elements in New World monkeys using PCR amplification. Six LTR elements of HERV-K family were identified from New World monkeys, represented by the squirrel and night monkeys. They showed a high degree of sequence homology(96-99%) with the human-specific HERV-K LTR elements. Phylogenetic analysis reveals that an LTR element (SM-1) from the squirrel monkey and another LTR element (NM-1) from the night monkey are very closely related to the human-specific HERV-K LTR elements with low degree of divergence. This finding suggests that some of LTR elements of HERV-K family have recently been proliferated in New World monkeys. A sequence in chromosome Xq26(AL034407) \ulcorner contains an HERV-K LTR element was shown to be present in the human genome, but is absent in the bonobo, chimpanzee, gorilla, orangutan, and gibbon. It has more than 99% homology to other human-specific HERV-K LTR elements. This sequence thus represents and isolated insertion of an evolving class of elements that may have made a particular contribution to human genomic plasticity.
HERV-K LTR elementsphylogenetic analysisPCRhuman chromosomeprimates
Korea Soc-Assoc-Inst
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