Effects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro

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dc.contributor.authorSei Ryang Oh-
dc.contributor.authorJunei Kinjo-
dc.contributor.authorYuichi Shii-
dc.contributor.authorTuyoshi Ikeda-
dc.contributor.authorToshihiro Nohara-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorJung Hee Kim-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T08:57:04Z-
dc.date.available2017-04-19T08:57:04Z-
dc.date.issued2000-
dc.identifier.issn0032-0943-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5095-
dc.description.abstractThe anticomplementary properties of kaikasaponin III (4) and soyasaponin I (8) from Pueraria Iobata and their hydrolytic analogs were investigated in vitro. Diglycosidic saponins [kaikasaponin I (3), soyasaponin III (7)] showed most potent anticomplementary activities, followed by monoglycosidic saponins [soyasapogenol B monoglucuronide (6), sophoradiol monoglucuronide (2)] and triglycosidic saponins [soyasaponin I (8), kaikasaponin III (4)], whereas sophoradiol (1) and soyasapogenol B (5) showed enhancement of hemolysis under the presence of serum on the classical pathway of complement system. But all of them showed very weak or no anticomplementary activities on the alternative pathway of complement system. The anticomplementary activity of the saponins was influenced by the nature of glucuronic acid, where the free acid forms (-COOH) showed much more potent activity than the sodium salt forms (-COO-Na+) or methyl ester forms (-COOCH3), and the reduced forms (-CH2OH) decreased the activity significantly.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleEffects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro-
dc.title.alternativeEffects of triterpenoids from Pueraria lobata on immunohemolysis: β-d-glucuronic acid plays an active role in anticomplementary activity in vitro-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number6-
dc.citation.endPage510-
dc.citation.startPage506-
dc.citation.volume66-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorJung Hee Kim-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeNameKinjo-
dc.contributor.alternativeNameShii-
dc.contributor.alternativeNameIkeda-
dc.contributor.alternativeNameNohara-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName김정희-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationPlanta Medica, vol. 66, no. 6, pp. 506-510-
dc.identifier.doi10.1055/s-2000-8614-
dc.subject.keywordAnticomplementary activity, glucuronic acid of saponin-
dc.subject.keywordLeguminosae-
dc.subject.keywordPueraria Iobata-
dc.subject.keywordSophoradiol saponins-
dc.subject.keywordSoyasapogenol B saponins-
dc.subject.localAnticomplementary activity, glucuronic acid of saponin-
dc.subject.localLeguminosae-
dc.subject.localleguminosae-
dc.subject.localPueraria Iobata-
dc.subject.localSophoradiol saponins-
dc.subject.localSoyasapogenol B saponins-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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