Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1

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Title
Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1
Author(s)
Ha Won Jeong; Mi Ran Kim; Kwang Hee Son; Mi Young Han; Ji Hong Ha; Matthieu Garnier; Laurent Meijer; Byoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 10, no. 16, pp. 1819-1822
Publication Year
2000
Abstract
A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 μM.
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0960-894X(00)00357-7
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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