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- Title
- Antibacterial activities of nonactin from Streptomyces viridochromogenes JM-4151
- Author(s)
- Jin Man Lee; Dong Sun Lee; Sang Han Lee; Soon Duk Hong; Jong Guk Kim
- Bibliographic Citation
- Journal of Life Science, vol. 10, no. 1, pp. 45-47
- Publication Year
- 2000
- Abstract
- Nonactin, known as an ionophore antibiotic, was antagonized by the actibity of quercetin, an oxygen radical scavenger. This compound generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. These results suggest that superoxide radical is important in the antibacterial action of this agent.
- Keyword
- nonactinantibacterial activitysuperoxide radicalstreptomyces viridochromogenes JM-4151
- ISSN
- I000-0128
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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