Antibacterial activities of nonactin from Streptomyces viridochromogenes JM-4151

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Title
Antibacterial activities of nonactin from Streptomyces viridochromogenes JM-4151
Author(s)
Jin Man Lee; Dong Sun Lee; Sang Han Lee; Soon Duk Hong; Jong Guk Kim
Bibliographic Citation
Journal of Life Science, vol. 10, no. 1, pp. 45-47
Publication Year
2000
Abstract
Nonactin, known as an ionophore antibiotic, was antagonized by the actibity of quercetin, an oxygen radical scavenger. This compound generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. These results suggest that superoxide radical is important in the antibacterial action of this agent.
Keyword
nonactinantibacterial activitysuperoxide radicalstreptomyces viridochromogenes JM-4151
ISSN
I000-0128
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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