Open Access@KRIBBDivision of Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ji Youn Nam | - |
| dc.contributor.author | Hyae Kyeong Kim | - |
| dc.contributor.author | Ju Young Kwon | - |
| dc.contributor.author | Mi Young Han | - |
| dc.contributor.author | Kwang Hee Son | - |
| dc.contributor.author | U C Lee | - |
| dc.contributor.author | J D Choi | - |
| dc.contributor.author | Byoung-Mog Kwon | - |
| dc.date.accessioned | 2017-04-19T08:57:06Z | - |
| dc.date.available | 2017-04-19T08:57:06Z | - |
| dc.date.issued | 2000 | - |
| dc.identifier.issn | 0163-3864 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5110 | - |
| dc.description.abstract | A new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated from a strain of Penicillium multicolor, and its structure was established using NMR spectroscopy and chemical evidence. The metabolite inhibited significantly the binding between the Grb2-SH2 domain and the phosphopeptide derived from the Shc protein and also blocked the protein - protein interactions of Grb2-Shc in cell-based experiments, with IC50 values of 5.3 and 50 μM, respectively. | - |
| dc.publisher | Amer Chem Soc | - |
| dc.title | 8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor | - |
| dc.title.alternative | 8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Natural Products | - |
| dc.citation.number | 9 | - |
| dc.citation.endPage | 1305 | - |
| dc.citation.startPage | 1303 | - |
| dc.citation.volume | 63 | - |
| dc.contributor.affiliatedAuthor | Hyae Kyeong Kim | - |
| dc.contributor.affiliatedAuthor | Mi Young Han | - |
| dc.contributor.affiliatedAuthor | Kwang Hee Son | - |
| dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
| dc.contributor.alternativeName | 남지연 | - |
| dc.contributor.alternativeName | 김혜경 | - |
| dc.contributor.alternativeName | 권주영 | - |
| dc.contributor.alternativeName | 한미영 | - |
| dc.contributor.alternativeName | 손광희 | - |
| dc.contributor.alternativeName | 이운철 | - |
| dc.contributor.alternativeName | 최정도 | - |
| dc.contributor.alternativeName | 권병목 | - |
| dc.identifier.bibliographicCitation | Journal of Natural Products, vol. 63, no. 9, pp. 1303-1305 | - |
| dc.identifier.doi | 10.1021/np0001169 | - |
| dc.description.journalClass | Y | - |
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