8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor

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dc.contributor.authorJi Youn Nam-
dc.contributor.authorHyae Kyeong Kim-
dc.contributor.authorJu Young Kwon-
dc.contributor.authorMi Young Han-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorU C Lee-
dc.contributor.authorJ D Choi-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T08:57:06Z-
dc.date.available2017-04-19T08:57:06Z-
dc.date.issued2000-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5110-
dc.description.abstractA new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated from a strain of Penicillium multicolor, and its structure was established using NMR spectroscopy and chemical evidence. The metabolite inhibited significantly the binding between the Grb2-SH2 domain and the phosphopeptide derived from the Shc protein and also blocked the protein - protein interactions of Grb2-Shc in cell-based experiments, with IC50 values of 5.3 and 50 μM, respectively.-
dc.publisherAmer Chem Soc-
dc.title8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor-
dc.title.alternative8-O-Methylsclerotiorinamine, Antagonist of the Grb2-SH2 Domain, Isolated from Penicillium multicolor-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number9-
dc.citation.endPage1305-
dc.citation.startPage1303-
dc.citation.volume63-
dc.contributor.affiliatedAuthorHyae Kyeong Kim-
dc.contributor.affiliatedAuthorMi Young Han-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName남지연-
dc.contributor.alternativeName김혜경-
dc.contributor.alternativeName권주영-
dc.contributor.alternativeName한미영-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName이운철-
dc.contributor.alternativeName최정도-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 63, no. 9, pp. 1303-1305-
dc.identifier.doi10.1021/np0001169-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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