Searching of cyclin-dependent kinase 4/cyclin D1 enzyme inhibition materials from the native plants = 자생 식물로 부터 Cyclin-dependent kinase 4/cyclin D1 저해물질의 탐색

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Title
Searching of cyclin-dependent kinase 4/cyclin D1 enzyme inhibition materials from the native plants = 자생 식물로 부터 Cyclin-dependent kinase 4/cyclin D1 저해물질의 탐색
Author(s)
Nack Do Sung; Mi Ran kim; Ji Hong Ha; Byoung-Mog Kwon; Ha Won Chung; Byung Tae Ahn; Shi Yong Ryu
Bibliographic Citation
Journal of Korean Society of Agricul Chem Biot, vol. 43, no. 3, pp. 174-178
Publication Year
2000
Abstract
To search CDK4/Cyclin D1 enzyme inhibition materials, methanol extracts of native eighty seven plant species in thirty seven families were screened in vitro for their inhibiting activities against CDK4/Cyclin D1 enzyme which are control to the normal cell division cycle in human body. Extracts of Paeonia suffruticosa, Saurus chinensis, Sanguisorba officinalis and Celastrus orbiculatus among them significantly inhibited above fifty percent (in 5 ㎍/㎖) against CDK4/ Cyclin D1 enzyme. Especially, the extracts of P. suffruticosaa and S. officinalis showed moderately strong inhibition. Also, cryptotanshinone was identified as active compound from a extracts of Salvia mitiorrhiza by spectroscopic analyses including 2D NMR experiments.
Keyword
CDK4/cyclin D1 enzyme inhibition materialssalvia mitiorrhizapaeonia suffruticosasanguisorba officinalis and cryptotanshinone
ISSN
0368-2897
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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