The effects of somatid on the cytotoxicity of cancer cells and human papillomavirus type 16 E6 and E7 oncogenes = 생기액의 세포독성 및 자궁경부암 바이러스(HPV 16 type) 암 유발인자 E6와 E7의 작용에 미치는 효과

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dc.contributor.authorOk Joung-
dc.contributor.authorYoung Sik Cho-
dc.contributor.authorCheong Weon Cho-
dc.contributor.authorKyung Ae Lee-
dc.contributor.authorJung Hyun Shim-
dc.contributor.authorMin Chul Cho-
dc.contributor.authorHong Soo Lee-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorSang Bom Kim-
dc.contributor.authorSue Nie Park-
dc.contributor.authorDo Young Yoon-
dc.date.accessioned2017-04-19T08:57:09Z-
dc.date.available2017-04-19T08:57:09Z-
dc.date.issued2000-
dc.identifier.issn0513-4242-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5129-
dc.description.abstractCervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year. A strong association between certain human papilloma viruses (HPV types 16 and 18) and cervical cancer has been well known. An extract of natural products, named as Somatid, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16. This Somatid inhibited the proliferation of human cervical cancer cell lines (C-33A, SiHa, CaSki) and HaCaT keratinocytes in a dose response manner. In vitro binding assay and ELISA showed that Somatid inhibited the in vitro biding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, Somatid inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of mRNA for E6 and E7 were also decreased by Somatid. Our data suggested that Somatid inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus can be used as a putative anti-HPV agent for the treatment of cervical carcinomas caused by HPV.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe effects of somatid on the cytotoxicity of cancer cells and human papillomavirus type 16 E6 and E7 oncogenes = 생기액의 세포독성 및 자궁경부암 바이러스(HPV 16 type) 암 유발인자 E6와 E7의 작용에 미치는 효과-
dc.title.alternativeThe effects of somatid on the cytotoxicity of cancer cells and human papillomavirus type 16 E6 and E7 oncogenes-
dc.typeArticle-
dc.citation.titleYakhak Hoeji-
dc.citation.number4-
dc.citation.endPage346-
dc.citation.startPage340-
dc.citation.volume44-
dc.contributor.affiliatedAuthorHong Soo Lee-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorDo Young Yoon-
dc.contributor.alternativeName정옥-
dc.contributor.alternativeName조영식-
dc.contributor.alternativeName조정원-
dc.contributor.alternativeName이경애-
dc.contributor.alternativeName심정현-
dc.contributor.alternativeName조민철-
dc.contributor.alternativeName이홍수-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName김상범-
dc.contributor.alternativeName박순희-
dc.contributor.alternativeName윤도영-
dc.identifier.bibliographicCitationYakhak Hoeji, vol. 44, no. 4, pp. 340-346-
dc.subject.keywordin vitro binding assay-
dc.subject.keywordenzyme-linked immunosorbent assay (ELISA)-
dc.subject.keywordE6 oncogene-
dc.subject.localIn vitro binding assay-
dc.subject.localin vitro binding assay-
dc.subject.localenzyme-linked immunosorbent assay (ELISA)-
dc.subject.localEnzyme-linked immunosorbent assay(ELISA)-
dc.subject.localenzyme-linked immunosorbent assay-
dc.subject.localELISA (enzyme-liked immunosorbent assay)-
dc.subject.localELISA-
dc.subject.localE6 oncogene-
dc.description.journalClassN-
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Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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