DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young Han Lee | - |
dc.contributor.author | Sun Sik Bae | - |
dc.contributor.author | Jeong Kon Seo | - |
dc.contributor.author | Inpyo Choi | - |
dc.contributor.author | Sung Ho Ryu | - |
dc.contributor.author | Pann Gill Suh | - |
dc.date.accessioned | 2017-04-19T08:57:10Z | - |
dc.date.available | 2017-04-19T08:57:10Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5133 | - |
dc.description.abstract | Phospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells | - |
dc.title.alternative | Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells | - |
dc.type | Article | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 474 | - |
dc.citation.startPage | 469 | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Inpyo Choi | - |
dc.contributor.alternativeName | 이영한 | - |
dc.contributor.alternativeName | 배선식 | - |
dc.contributor.alternativeName | 서정권 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.contributor.alternativeName | 류성호 | - |
dc.contributor.alternativeName | 서판길 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, vol. 10, no. 4, pp. 469-474 | - |
dc.subject.keyword | interleukin 6 | - |
dc.subject.keyword | PC12 cells | - |
dc.subject.keyword | phospholipase C-γ1 | - |
dc.subject.keyword | signal transduction | - |
dc.subject.keyword | tyrosine phosphorylation | - |
dc.subject.local | Interleukin 6 | - |
dc.subject.local | interleukin 6 | - |
dc.subject.local | interleukin 6 (IL-6) | - |
dc.subject.local | PC12 cells | - |
dc.subject.local | Phospholipase Cγ1 | - |
dc.subject.local | phospholipase Cγ1 | - |
dc.subject.local | phospholipase C-γ1 | - |
dc.subject.local | Signal transduction | - |
dc.subject.local | Signal trasduction | - |
dc.subject.local | signal transduction | - |
dc.subject.local | Tyrosine phosphorylation | - |
dc.subject.local | Tyrosine Phosphorylation | - |
dc.subject.local | tyrosine phosphorylation | - |
dc.description.journalClass | Y | - |
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