Interleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells

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dc.contributor.authorYoung Han Lee-
dc.contributor.authorSun Sik Bae-
dc.contributor.authorJeong Kon Seo-
dc.contributor.authorInpyo Choi-
dc.contributor.authorSung Ho Ryu-
dc.contributor.authorPann Gill Suh-
dc.date.accessioned2017-04-19T08:57:10Z-
dc.date.available2017-04-19T08:57:10Z-
dc.date.issued2000-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5133-
dc.description.abstractPhospholipase C (PLC)-γ1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-γ1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-γ1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-γ1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleInterleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells-
dc.title.alternativeInterleukin-6-induced tyrosine phosphorylation of phospholipase C-γ1 in PC12 cells-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number4-
dc.citation.endPage474-
dc.citation.startPage469-
dc.citation.volume10-
dc.contributor.affiliatedAuthorInpyo Choi-
dc.contributor.alternativeName이영한-
dc.contributor.alternativeName배선식-
dc.contributor.alternativeName서정권-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName류성호-
dc.contributor.alternativeName서판길-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 10, no. 4, pp. 469-474-
dc.subject.keywordinterleukin 6-
dc.subject.keywordPC12 cells-
dc.subject.keywordphospholipase C-γ1-
dc.subject.keywordsignal transduction-
dc.subject.keywordtyrosine phosphorylation-
dc.subject.localInterleukin 6-
dc.subject.localinterleukin 6-
dc.subject.localinterleukin 6 (IL-6)-
dc.subject.localPC12 cells-
dc.subject.localPhospholipase Cγ1-
dc.subject.localphospholipase Cγ1-
dc.subject.localphospholipase C-γ1-
dc.subject.localSignal transduction-
dc.subject.localSignal trasduction-
dc.subject.localsignal transduction-
dc.subject.localTyrosine phosphorylation-
dc.subject.localTyrosine Phosphorylation-
dc.subject.localtyrosine phosphorylation-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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