Analysis of tnrA alleles which result in a glucose-resistant sporulation phenotype in Bacillus subtilis

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Title
Analysis of tnrA alleles which result in a glucose-resistant sporulation phenotype in Bacillus subtilis
Author(s)
Byung Sik Shin; Soo Keun Choi; Issar Smith; Seung Hwan Park
Bibliographic Citation
Journal of Bacteriology, vol. 182, no. 17, pp. 5009-5012
Publication Year
2000
Abstract
Bacillus subtilis cells cannot sporulate in the presence of catabolites such as glucose. During the analysis of Tn10-generated mutants, we found that deletion of the C-terminal region of the tnrA gene, which encodes a global regulator that positively regulates a number of genes in response to nitrogen limitation, results in a catabolite-resistant sporulation phenotype. Analyses of nrg-lacZ and nasB-lacZ, which are activated by TnrA under nitrogen limitation, showed that C-terminally truncated TnrA activates nitrogen-regulated genes constitutively. The relief of catabolite repression of sporulation may result from the uncontrolled expression of the TnrA-regulated genes.
ISSN
0021-9193
Publisher
Amer Soc Microb
DOI
http://dx.doi.org/10.1128/JB.182.17.5009-5012.2000
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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