Hydrogen peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase and p38 associated with protein kinase C

Cited 12 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorMichael Lee-
dc.contributor.authorSung Su Yea-
dc.date.accessioned2017-04-19T08:57:15Z-
dc.date.available2017-04-19T08:57:15Z-
dc.date.issued2000-
dc.identifier.issn0162-3109-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5171-
dc.description.abstractThis study examined the immunomodulatory effects of hydrogen peroxide (H2O2) in B6C3F1 mouse splenic lymphocytes. H2O2 produced a marked and dose-related inhibition of both lipopolysaccharide (LPS)-induced B-cell proliferation and concanavalin A (Con A)-induced T-cell proliferation. Unexpectedly, little effect was observed with H2O2 on the antibody-forming cell (AFC) response to the polyclonal B-cell activator, LPS. It was also observed that H2O2 did not have any detectable effect on forskolin-stimulated adenylate cyclase, indicating that cyclic AMP (cAMP) is not a mediator of H2O2-induced suppression of the immune response. Rather, LPS-induced activation of protein kinase C (PKC) was completely inhibited when cells were pretreated with H2O2 for 18 h, although PKC activity was increased approximately twofold following treatment with H2O2 for 10 min. In addition, H2O2 pretreatment blocked the phosphorylation of two stress-activated mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase (JNK) and p38 by LPS in a concentration-dependent fashion. Therefore, these data suggest that H2O2 suppresses immune response through the desensitization of PKC, which subsequently results in inhibition of JNK and p38.-
dc.publisherElsevier-
dc.titleHydrogen peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase and p38 associated with protein kinase C-
dc.title.alternativeHydrogen peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase and p38 associated with protein kinase C-
dc.typeArticle-
dc.citation.titleImmunopharmacology-
dc.citation.number2-
dc.citation.endPage172-
dc.citation.startPage165-
dc.citation.volume48-
dc.contributor.affiliatedAuthorMichael Lee-
dc.contributor.alternativeName이미가엘-
dc.contributor.alternativeName여성수-
dc.identifier.bibliographicCitationImmunopharmacology, vol. 48, no. 2, pp. 165-172-
dc.identifier.doi10.1016/S0162-3109(00)00202-2-
dc.subject.keywordhydrogen peroxide-
dc.subject.keywordprotein kinase C-
dc.subject.keywordMAP kinase-
dc.subject.keywordimmunosuppression-
dc.subject.keywordlipopolysaccharide-
dc.subject.localHydrogen peroxide-
dc.subject.localhydrogen peroxide-
dc.subject.localProtein kinase C-
dc.subject.localprotein kinase C-
dc.subject.localprotein kinase c-
dc.subject.localMAP kinases-
dc.subject.localmap kinase-
dc.subject.localMAP kinase-
dc.subject.localImmunosuppression-
dc.subject.localimmunosuppression-
dc.subject.locallipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharide-
dc.subject.locallipopolysaccharide-
dc.subject.localLipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharides-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.