Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

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dc.contributor.authorJi Suk Lee-
dc.contributor.authorJin Woong Kim-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorHyun Sun Lee-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorYuan Shiun Chang-
dc.date.accessioned2017-04-19T08:57:16Z-
dc.date.available2017-04-19T08:57:16Z-
dc.date.issued2000-
dc.identifier.issn01633864-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5177-
dc.description.abstractInvestigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cγ1 (PLCγ1) inhibitors (1-6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCγ1 in vitro with IC50 values of 9.5-44.6 μM and inhibited the proliferation of human cancer cells with IC50 values of 0.5-6.5 μg/mL.-
dc.publisherAmer Chem Soc-
dc.titleInhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla-
dc.title.alternativeInhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number6-
dc.citation.endPage756-
dc.citation.startPage753-
dc.citation.volume63-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorHyun Sun Lee-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName이지숙-
dc.contributor.alternativeName김진웅-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName이현선-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeNameChang-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 63, no. 6, pp. 753-756-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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