Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice

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Title
Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice
Author(s)
Sung Ha Jin; Jin Kyu Park; Ki Yeul Nam; Sue Nie Park; Noh Pal Jung
Bibliographic Citation
Journal of Ethnopharmacology, vol. 66, no. 2, pp. 123-129
Publication Year
1999
Abstract
The effects of two ginseng saponins having a different ratio of protopanaxadiol (PD) and protopanaxatriol saponins (PT) on the learning impairment induced by scopolamine, and learning and memory in mice were investigated in a passive avoidance task and a Morris water maze task. The ratio of PD and PT was 1.24 and 1.46, respectively. Before training, the ginseng saponins were administered intraperitoneally at doses of 50 and 100 mg/kg. The two saponins improved the scopolamine-induced learning impairment at different dosages in mice, 50 and 100 mg/kg, respectively. However, the two saponins did not show a favorable effect on learning and memory in normal mice. Korean red ginseng saponin with a low PD/PT ratio had an improving effect on spatial working memory, but the saponin with a high PD/PT ratio did not. This finding suggests that the PD/PT ratio of the ginseng saponins may be an important factor in the pharmacological role of red ginseng as a medicinal herb.
Keyword
Korean red ginseng saponinPD/PT ratiomemoryscopolamine
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0378-8741(98)00190-1
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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