Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells

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Title
Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells
Author(s)
Kyung Seop AhnJung Hee KimSei Ryang Oh; Shi Yong Ryu; Hyeong Kyu Lee
Bibliographic Citation
Planta Medica, vol. 66, no. 7, pp. 641-644
Publication Year
2000
Abstract
The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A cell-to-cell adhesion assay showed that 3,5-dihydroxy-4'-methoxystilbene and 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucopyranoside as well as resveratrol blocked significantly TNF-α-inducing cell-cell adhesion between human umbilical vein endothelial cells (HUVEC) and THP-1 cells.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2000-8634
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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