Phylogenetic analysis of retroposon family as exemplified on human chromosome 13: further evidence for recent proliferation

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Title
Phylogenetic analysis of retroposon family as exemplified on human chromosome 13: further evidence for recent proliferation
Author(s)
Heui Soo Kim; Byung Hwa Hyun; Timothy J Crow
Bibliographic Citation
Molecules and Cells, vol. 10, no. 3, pp. 356-360
Publication Year
2000
Abstract
The retroposon SINE-R.C2 was first identified as a human-specific insertion in the complement C2 gene. In our previous study, SINE-R type retroposons, derived from the endogenous retrovirus HERV-K family, have been found to be hominoid specific. In this report on human chromosome 13, we identified eighteen new SINE-R retroposons resembling those we have previously reported on the sex chromosomes and on chromosomes 7 and 17. Phylogenetic analysis using the neighbor-joining method revealed that four SINE-R retroposons (13-16, 21, 23, 25) on chromosome 13 were closely related to the human-specific retroposon SINE-R.C2, with a high degree of sequence homology (95-97%). Such elements differ from the HERV-K10 LTR sequence from which they are derived in being deleted for the promoter region. Therefore while the evidence adds to the case that some classes of SINE-R element have continued to proliferate in hominid and hominoid evolution and may, as in the case of Fukuyama type muscular dystrophy, be a cause of insertional mutagenesis, they are less likely than the HERV-K10 LTR to have a positive effect on host gene activity.
Keyword
HERV-K LTRhuman chromosome 13phylogenySINE-R retroposon
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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