Effects of Opuntia ficus-indica extract on immune cell activation = 손바닥선인장(제주도 기념물 35호) 추출물이 면역계세포의 활성화에 미치는 영향

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Title
Effects of Opuntia ficus-indica extract on immune cell activation = 손바닥선인장(제주도 기념물 35호) 추출물이 면역계세포의 활성화에 미치는 영향
Author(s)
Chang Jong Moon; Seung Joon Kim; Mee Jung Ahn; Sun Joo Lee; Kyu Shik Jeong; Sang Joon Park; Do Young Yoon; Yong Kyung Choe; Tae Kyun Shin
Bibliographic Citation
Korean Journal of Life Sciences, vol. 10, no. 4, pp. 362-367
Publication Year
2000
Abstract
Opuntia ficus-indca(Op) extract has been claimed to have several therapeutic properties in oriental medicine including anti-inflammatory and anti-rheumatoid arthritis effects. Little is known of its effect on the activation of immune cells such as T cells and macrophages. To evaluate the functional effect of Op extract on immune cells, we examined whether Op extract stimulates the proliferation of T cells and the secretion of cytokines including IL-1 beta, IL-6 and tumor necrosis factor-alpha in THP-1 cell lines by RT-PCR. Op extract significantly enhanced the proliferation of T cell clone(D10S). Transcription of cytokines including IL-1 beta, IL-6, and TNF-alpha peaked 6 hrs after exposure to Op extract(100g/ml) in the THP-1 cell line and declined and declined thereafter. In an experiment to test the dose dependency of transcription of cytokines, transcription increased at a dose of 10 g/ml and the maximum expression was obtained at 100 g/ml, 6 hrs after exposure to Op extract. These findings suggest that Op extract is a potent stimulant of immune cells including T cells and macrophages, which acts by stimulating T cell proliferation and upregulating cytokines. These phenomena imply that some edible plants may be beneficial to living animals through the activation of immune functions.
Keyword
opunitia ficus-indicacactuslymphocytesmacrophagescytokines
ISSN
I000-0052
Publisher
South Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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