Effects of transferrin on the modulation of cytokine production on mouse spleen cells

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dc.contributor.authorSi Yun Ryu-
dc.contributor.authorKyu Shik Jeong-
dc.contributor.authorSang Joon Park-
dc.contributor.authorByoung Gil Mheen-
dc.contributor.authorHwa Young Son-
dc.contributor.authorWon Kee Yoon-
dc.contributor.authorSung Whan Cho-
dc.contributor.authorBae Keun Park-
dc.contributor.authorSung Ho Kim-
dc.date.accessioned2017-04-19T08:57:25Z-
dc.date.available2017-04-19T08:57:25Z-
dc.date.issued1998-
dc.identifier.issn0258-851X-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5253-
dc.description.abstractIn order to investigate the the effects of transferrin (Tf) on the production of cytokines, mouse spleen cells were treated with various concentrations of apo- and holo-Tf, and then the production of IL-6, IFNγ and the expression of mRNA for TNF α was determined. The distribution of Tf, macrophages and T cells in the mouse mammary glands was also examined. IL-6 and IFNγ producing capabilities of the unstimulated spleen cells in the presence of apo and holo-Tf were increased in a dose dependent manner, while the cells stimulated with anti-CD3 had no significant effects on production in thd presence of graded concentrations of Tf. The relative abundance of TNF α mRNA was significantly affected by the concentration of Tf. During early involution almost all of the secretory epithelial cells and the secretion in the alveoli showed a very strong positive reaction to transferrin antibody, and macrophages and T cells were distributed in the lumen, alveolar epithelial layer and connective tissue area. These findings suggest that the upregulated patterns of these cytokines and distribution of immune cells may play a beneficial role in the augmentation of host's defense mechanisms during involution.-
dc.publisherInt Inst Anticancer Research-
dc.titleEffects of transferrin on the modulation of cytokine production on mouse spleen cells-
dc.title.alternativeEffects of transferrin on the modulation of cytokine production on mouse spleen cells-
dc.typeArticle-
dc.citation.titlein Vivo-
dc.citation.number2-
dc.citation.endPage194-
dc.citation.startPage187-
dc.citation.volume12-
dc.contributor.affiliatedAuthorKyu Shik Jeong-
dc.contributor.affiliatedAuthorSang Joon Park-
dc.contributor.affiliatedAuthorByoung Gil Mheen-
dc.contributor.affiliatedAuthorWon Kee Yoon-
dc.contributor.alternativeName류시연-
dc.contributor.alternativeName정규식-
dc.contributor.alternativeName박상준-
dc.contributor.alternativeName민병길-
dc.contributor.alternativeName손화영-
dc.contributor.alternativeName윤원기-
dc.contributor.alternativeName조성환-
dc.contributor.alternativeName박배근-
dc.contributor.alternativeName김성호-
dc.identifier.bibliographicCitationin Vivo, vol. 12, no. 2, pp. 187-194-
dc.subject.keywordtransferrin-
dc.subject.keywordcytokine-
dc.subject.keywordmouse spleen cells-
dc.subject.keywordmouse mammary gland-
dc.subject.localtransferrin-
dc.subject.localcytokine-
dc.subject.localCytokines-
dc.subject.localCytokine-
dc.subject.localmouse spleen cells-
dc.subject.localmouse mammary gland-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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