DC Field | Value | Language |
---|---|---|
dc.contributor.author | Si Yun Ryu | - |
dc.contributor.author | Kyu Shik Jeong | - |
dc.contributor.author | Sang Joon Park | - |
dc.contributor.author | Byoung Gil Mheen | - |
dc.contributor.author | Hwa Young Son | - |
dc.contributor.author | Won Kee Yoon | - |
dc.contributor.author | Sung Whan Cho | - |
dc.contributor.author | Bae Keun Park | - |
dc.contributor.author | Sung Ho Kim | - |
dc.date.accessioned | 2017-04-19T08:57:25Z | - |
dc.date.available | 2017-04-19T08:57:25Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5253 | - |
dc.description.abstract | In order to investigate the the effects of transferrin (Tf) on the production of cytokines, mouse spleen cells were treated with various concentrations of apo- and holo-Tf, and then the production of IL-6, IFNγ and the expression of mRNA for TNF α was determined. The distribution of Tf, macrophages and T cells in the mouse mammary glands was also examined. IL-6 and IFNγ producing capabilities of the unstimulated spleen cells in the presence of apo and holo-Tf were increased in a dose dependent manner, while the cells stimulated with anti-CD3 had no significant effects on production in thd presence of graded concentrations of Tf. The relative abundance of TNF α mRNA was significantly affected by the concentration of Tf. During early involution almost all of the secretory epithelial cells and the secretion in the alveoli showed a very strong positive reaction to transferrin antibody, and macrophages and T cells were distributed in the lumen, alveolar epithelial layer and connective tissue area. These findings suggest that the upregulated patterns of these cytokines and distribution of immune cells may play a beneficial role in the augmentation of host's defense mechanisms during involution. | - |
dc.publisher | Int Inst Anticancer Research | - |
dc.title | Effects of transferrin on the modulation of cytokine production on mouse spleen cells | - |
dc.title.alternative | Effects of transferrin on the modulation of cytokine production on mouse spleen cells | - |
dc.type | Article | - |
dc.citation.title | in Vivo | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 194 | - |
dc.citation.startPage | 187 | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Kyu Shik Jeong | - |
dc.contributor.affiliatedAuthor | Sang Joon Park | - |
dc.contributor.affiliatedAuthor | Byoung Gil Mheen | - |
dc.contributor.affiliatedAuthor | Won Kee Yoon | - |
dc.contributor.alternativeName | 류시연 | - |
dc.contributor.alternativeName | 정규식 | - |
dc.contributor.alternativeName | 박상준 | - |
dc.contributor.alternativeName | 민병길 | - |
dc.contributor.alternativeName | 손화영 | - |
dc.contributor.alternativeName | 윤원기 | - |
dc.contributor.alternativeName | 조성환 | - |
dc.contributor.alternativeName | 박배근 | - |
dc.contributor.alternativeName | 김성호 | - |
dc.identifier.bibliographicCitation | in Vivo, vol. 12, no. 2, pp. 187-194 | - |
dc.subject.keyword | transferrin | - |
dc.subject.keyword | cytokine | - |
dc.subject.keyword | mouse spleen cells | - |
dc.subject.keyword | mouse mammary gland | - |
dc.subject.local | transferrin | - |
dc.subject.local | cytokine | - |
dc.subject.local | Cytokines | - |
dc.subject.local | Cytokine | - |
dc.subject.local | mouse spleen cells | - |
dc.subject.local | mouse mammary gland | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.