Abnormal synaptic organization between granule cells and Purkinje cells in the new ataxic mutant mouse, pogo
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- Abnormal synaptic organization between granule cells and Purkinje cells in the new ataxic mutant mouse, pogo
- Young Gil Jeong; Byung Hwa Hyun
- Bibliographic Citation
- Neuroscience Letters, vol. 294, no. 2, pp. 77-80
- Publication Year
- The pogo mouse is a new ataxic mutant derived from the Korean wild mouse. The pathological manifestations include difficulty in maintaining normal posture and the inability to walk straight. The ataxia becomes apparent at about 2 weeks of age. Electron microscopic studies of the pogo/pogo homozygous cerebellum, revealed that the ectopic spines emanating from the primary dendrite of Purkinje cells were observed. Major difference between pogo/pogo homozygous and non-affected pogo/+ heterozygous was the synaptic organization of the molecular layer. Parallel fiber varicosities were larger than normal and a single fiber often established synaptic contacts with up to four dendritic spines of a Purkinje cell. This correlation between the presence of altered synaptic organization in the cerebellum and ataxia in pogo/pogo mutant mice warrants further investigation.
- abnormal synapseataxic mutantcerebellumectopic spineelectron microscopyparallel fiberpurkinje cell dendritic spine
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