5,6-dinitrophenyl and 5-aminophenyl-6-nitrophenyl analogues of the acat inhibitor 5,6-diphenyl-3-alkylaminopyridazines

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Title
5,6-dinitrophenyl and 5-aminophenyl-6-nitrophenyl analogues of the acat inhibitor 5,6-diphenyl-3-alkylaminopyridazines
Author(s)
Lucio Toma; Donatella Nava; Giuseppe Celentano; Maria Paola Giovannoni; Vittorio Dal Piaz; Byoung-Mog Kwon; Mi Kyung Kim; Young Kook Kim; Daniela Barlocco
Bibliographic Citation
Heterocycles, vol. 53, no. 12, pp. 2709-2718
Publication Year
2000
Abstract
A series of dinitro and monoamino-mononitro analogues of the 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their structure was assigned on the basis of mono and bidimensional NMR experiments. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate the activity of the compounds to their structural features.
ISSN
0385-5414
Publisher
Elsevier
DOI
http://dx.doi.org/10.3987/COM-00-9037
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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