Curdlan gels as protein drug delivery vehicles

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Title
Curdlan gels as protein drug delivery vehicles
Author(s)
Beom Soo Kim; In Duck Jung; Jong Sik Kim; Jung Heon Lee; In Young Lee; Kyung Bok Lee
Bibliographic Citation
Biotechnology Letters, vol. 22, no. 14, pp. 1127-1130
Publication Year
2000
Abstract
The use of curdlan, a natural β-1,3-glucan, in protein drug delivery vehicles was studied by carrying out in vitro release studies with curdlan gels containing bovine serum albumin (BSA) as a model protein. Addition of urea (8 M) decreased the gel formation temperature to 37 °C. Curdlan was hydroxyethylated in order to form gels under mild conditions such as physiological temperature and pH. In gels formed in 8 M urea solution, urea was almost released after 2 h while B SA was completely released after 45-100 h. The total time for complete release of BSA increased with curdlan concentration within gels. The strength of hydroxyethylated curdlan gels (385.7 dyne cm-2) was weaker than that of curdlan gels formed in 8 M urea solution (6277 dyne cm-2).
Keyword
CurdlanGelHydroxyethylationProtein drug deliveryUrea
ISSN
0141-5492
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1005636205036
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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