Phylogenetic analysis of a retroposon family as represented on the human X chromosome

Cited 4 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorHeui Soo Kim-
dc.contributor.authorByung Hwa Hyun-
dc.contributor.authorJoo Young Choi-
dc.contributor.authorTimothy J Crow-
dc.description.abstractSINE-R elements constitute a class of retroposons derived from the long terminal repeat (LTR) of the human endogenous retrovirus HERV-K family that are present in hominoid primates and active in the human genome. In an investigation of the X chromosome, we identified twenty-five SINE-R elements with between 89.6 and 97.7% homology with the SINE-R.C2 element that is human specific, originally identified in the gene for the C2 component of complement. SINE-R.C2 and a sequence HS307 that we previously identified in a region of Xq21.3 that has a recently created homology with a 4 Mb block in Yp11.2 are amongst the group of elements that have diverged furthest from the parent HERV-K10 sequence. The sequences on the X chromosome resemble those that we previously described on chromosomes 7 and 17 and the Y chromosome, with a similar range of variation. Phylogenetic analysis from the retroposon family including those of African great apes using the neighbor-joining method suggests that the SINE-R retroposon family have evolved independently during primate evolution. Further investigation of SINE-R elements on the sex chromosomes, particularly in recently created regions of X-Y homology, may cast light on the timing of the retroposition process and its possible relevance to recent evolutionary change.-
dc.publisherGenetics Soc Japan-
dc.titlePhylogenetic analysis of a retroposon family as represented on the human X chromosome-
dc.title.alternativePhylogenetic analysis of a retroposon family as represented on the human X chromosome-
dc.citation.titleGenes & Genetic Systems-
dc.contributor.affiliatedAuthorByung Hwa Hyun-
dc.identifier.bibliographicCitationGenes & Genetic Systems, vol. 75, no. 4, pp. 197-202-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.