DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyo Jeong Hong | - |
dc.contributor.author | Jae W Lee | - |
dc.contributor.author | Sung Sup Park | - |
dc.contributor.author | Young Jun Kang | - |
dc.contributor.author | Sun Young Chang | - |
dc.contributor.author | Kwang Mi Kim | - |
dc.contributor.author | Jae Ouk Kim | - |
dc.contributor.author | Krishna K Murthy | - |
dc.contributor.author | Jennifer S Payne | - |
dc.contributor.author | Sung Kwan Yoon | - |
dc.contributor.author | Mi Jeong Park | - |
dc.contributor.author | In Chull Kim | - |
dc.contributor.author | Joong Gon Kim | - |
dc.contributor.author | Chang Yuil Kang | - |
dc.date.accessioned | 2017-04-19T08:57:40Z | - |
dc.date.available | 2017-04-19T08:57:40Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1053-8550 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5339 | - |
dc.description.abstract | The interaction of 4-1BB and its ligand plays an important role in the regulation of T-cell-mediated immune responses. In this study, the authors examined the effect of a humanized anti-4-1BB monoclonal antibody (H4B4) on ovalbumin-induced immune responses in baboons. Previously, a mouse monoclonal antibody, 4B4 against the human 4-1BB molecule, was generated and characterized. Based on this antibody, a humanized version of 4B4 monoclonal antibody was constructed and the resultant antibody, H4B4, showed full recovery of the binding activity of the original antibody 4B4: a 1.5-fold increase in affinity for 4-1BB. In addition, H4B4 mediated antibody-dependent cellular cytotoxicity of activated human peripheral blood T cells and CEM cells in a dose-dependent manner. Weekly administration of H4B4 at doses of 1 or 4 mg/kg could suppress immunoglobulin G production against ovalbumin. This was not a result of the overall immune suppression, because the numbers of B and T cells and the total immunoglobulin G production were not altered during treatment with H4B4. These findings suggest that treatment with H4B4 may be a valid therapeutic approach to control unwanted immune responses in persons with autoimmune diseases. | - |
dc.publisher | Kluwer | - |
dc.title | A humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates | - |
dc.title.alternative | A humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates | - |
dc.type | Article | - |
dc.citation.title | Journal of Immunotherapy | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 621 | - |
dc.citation.startPage | 613 | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Hyo Jeong Hong | - |
dc.contributor.affiliatedAuthor | Sung Sup Park | - |
dc.contributor.affiliatedAuthor | Young Jun Kang | - |
dc.contributor.alternativeName | 홍효정 | - |
dc.contributor.alternativeName | 이재 | - |
dc.contributor.alternativeName | 박성섭 | - |
dc.contributor.alternativeName | 강영준 | - |
dc.contributor.alternativeName | 장선영 | - |
dc.contributor.alternativeName | 김광미 | - |
dc.contributor.alternativeName | 김재욱 | - |
dc.contributor.alternativeName | Murthy | - |
dc.contributor.alternativeName | Payne | - |
dc.contributor.alternativeName | 윤성관 | - |
dc.contributor.alternativeName | 박미정 | - |
dc.contributor.alternativeName | 김인철 | - |
dc.contributor.alternativeName | 김중곤 | - |
dc.contributor.alternativeName | 강창열 | - |
dc.identifier.bibliographicCitation | Journal of Immunotherapy, vol. 23, no. 6, pp. 613-621 | - |
dc.identifier.doi | 10.1097/00002371-200011000-00002 | - |
dc.subject.keyword | Autoimmune disease | - |
dc.subject.keyword | Humanized anti-4-1BB monoclonal antibody | - |
dc.subject.keyword | Immunosuppression | - |
dc.subject.keyword | Immunotherapy | - |
dc.subject.keyword | Nonhuman primate | - |
dc.subject.local | Autoimmune disease | - |
dc.subject.local | autoimmune disease | - |
dc.subject.local | Autoimmune diseases | - |
dc.subject.local | Humanized anti-4-1BB monoclonal antibody | - |
dc.subject.local | Immunosuppression | - |
dc.subject.local | immunosuppression | - |
dc.subject.local | Immunotherapy | - |
dc.subject.local | immunotherapy | - |
dc.subject.local | Immunothrapy | - |
dc.subject.local | Non-human primate | - |
dc.subject.local | Non-human primates | - |
dc.subject.local | Nonhuman primate | - |
dc.subject.local | Nonhuman primate (NHP) | - |
dc.subject.local | Nonhuman primates | - |
dc.subject.local | non-human primate | - |
dc.subject.local | nonhuman primates | - |
dc.description.journalClass | Y | - |
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