A humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates

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dc.contributor.authorHyo Jeong Hong-
dc.contributor.authorJae W Lee-
dc.contributor.authorSung Sup Park-
dc.contributor.authorYoung Jun Kang-
dc.contributor.authorSun Young Chang-
dc.contributor.authorKwang Mi Kim-
dc.contributor.authorJae Ouk Kim-
dc.contributor.authorKrishna K Murthy-
dc.contributor.authorJennifer S Payne-
dc.contributor.authorSung Kwan Yoon-
dc.contributor.authorMi Jeong Park-
dc.contributor.authorIn Chull Kim-
dc.contributor.authorJoong Gon Kim-
dc.contributor.authorChang Yuil Kang-
dc.date.accessioned2017-04-19T08:57:40Z-
dc.date.available2017-04-19T08:57:40Z-
dc.date.issued2000-
dc.identifier.issn10538550-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5339-
dc.description.abstractThe interaction of 4-1BB and its ligand plays an important role in the regulation of T-cell-mediated immune responses. In this study, the authors examined the effect of a humanized anti-4-1BB monoclonal antibody (H4B4) on ovalbumin-induced immune responses in baboons. Previously, a mouse monoclonal antibody, 4B4 against the human 4-1BB molecule, was generated and characterized. Based on this antibody, a humanized version of 4B4 monoclonal antibody was constructed and the resultant antibody, H4B4, showed full recovery of the binding activity of the original antibody 4B4: a 1.5-fold increase in affinity for 4-1BB. In addition, H4B4 mediated antibody-dependent cellular cytotoxicity of activated human peripheral blood T cells and CEM cells in a dose-dependent manner. Weekly administration of H4B4 at doses of 1 or 4 mg/kg could suppress immunoglobulin G production against ovalbumin. This was not a result of the overall immune suppression, because the numbers of B and T cells and the total immunoglobulin G production were not altered during treatment with H4B4. These findings suggest that treatment with H4B4 may be a valid therapeutic approach to control unwanted immune responses in persons with autoimmune diseases.-
dc.publisherKluwer-
dc.titleA humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates-
dc.title.alternativeA humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates-
dc.typeArticle-
dc.citation.titleJournal of Immunotherapy-
dc.citation.number6-
dc.citation.endPage621-
dc.citation.startPage613-
dc.citation.volume23-
dc.contributor.affiliatedAuthorSung Sup Park-
dc.contributor.alternativeName홍효정-
dc.contributor.alternativeName이재-
dc.contributor.alternativeName박성섭-
dc.contributor.alternativeName강영준-
dc.contributor.alternativeName장선영-
dc.contributor.alternativeName김광미-
dc.contributor.alternativeName김재욱-
dc.contributor.alternativeNameMurthy-
dc.contributor.alternativeNamePayne-
dc.contributor.alternativeName윤성관-
dc.contributor.alternativeName박미정-
dc.contributor.alternativeName김인철-
dc.contributor.alternativeName김중곤-
dc.contributor.alternativeName강창열-
dc.identifier.bibliographicCitationJournal of Immunotherapy, vol. 23, no. 6, pp. 613-621-
dc.identifier.doi10.1097/00002371-200011000-00002-
dc.subject.keywordAutoimmune disease-
dc.subject.keywordHumanized anti-4-1BB monoclonal antibody-
dc.subject.keywordImmunosuppression-
dc.subject.keywordImmunotherapy-
dc.subject.keywordNonhuman primate-
dc.subject.localAutoimmune disease-
dc.subject.localHumanized anti-4-1BB monoclonal antibody-
dc.subject.localImmunosuppression-
dc.subject.localImmunotherapy-
dc.subject.localNonhuman primate-
dc.subject.localNon-human primate-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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