DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young Jin Jeon | - |
dc.contributor.author | Sang Bae Han | - |
dc.contributor.author | Sang Han Lee | - |
dc.contributor.author | Hyoung Chin Kim | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.contributor.author | Hwan Mook Kim | - |
dc.date.accessioned | 2017-04-19T08:57:42Z | - |
dc.date.available | 2017-04-19T08:57:42Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | 10.1016/S1567-5769(00)00003-5 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5351 | - |
dc.description.abstract | In our previous studies, we showed that angelan, a polysaccharide purified from Angelica gigas Nakai, specifically activated macrophages to induce cytokines including inducible nitric oxide synthase (iNOS) which has strong anti-tumor activities [Immunopharmacology, 1999; 43: 1.]. In the present study, we investigated the intracellular signal transduction pathways involved in the angelan-induced iNOS synthesis by murine macrophages. Protein tyrosine phosphorylation was induced within 5 min by angelan, and the blocking of protein tyrosine kinases (PTKs) inhibited down-stream pathways leading to iNOS production in response to angelan. Treament of RAW 264.7 cells with angelan resulted in significant activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and p38, while stress-activated protein kinase/c-Jun NH2 terminal kinase (SAPK/JNK) was not activated by angelan. The specific p38 inhibitor SB203580 abrogated the angelan-induced iNOS synthesis, whereas the selective mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1 (MEK-1) inhibitor PD98059 did not affect the iNOS induction. In conclusion, we demonstrate that PTK and p38 MAPK activation are required to transduce signals leading to iNOS expression in angelan-stimulated murine macrophages. | - |
dc.publisher | Elsevier | - |
dc.title | Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages | - |
dc.title.alternative | Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages | - |
dc.type | Article | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 245 | - |
dc.citation.startPage | 237 | - |
dc.citation.volume | 1 | - |
dc.contributor.affiliatedAuthor | Young Jin Jeon | - |
dc.contributor.affiliatedAuthor | Sang Bae Han | - |
dc.contributor.affiliatedAuthor | Sang Han Lee | - |
dc.contributor.affiliatedAuthor | Hyoung Chin Kim | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
dc.contributor.alternativeName | 전영진 | - |
dc.contributor.alternativeName | 한상배 | - |
dc.contributor.alternativeName | 이상한 | - |
dc.contributor.alternativeName | 김형진 | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.contributor.alternativeName | 김환묵 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, vol. 1, no. 2, pp. 237-245 | - |
dc.identifier.doi | 10.1016/S1567-5769(00)00003-5 | - |
dc.subject.keyword | angelica gigas Nakai | - |
dc.subject.keyword | angelan | - |
dc.subject.keyword | macrophages | - |
dc.subject.keyword | p38 | - |
dc.subject.keyword | PTK | - |
dc.subject.local | Angelica gigas Nakai | - |
dc.subject.local | angelica gigas Nakai | - |
dc.subject.local | angelan | - |
dc.subject.local | Angelan | - |
dc.subject.local | macrophages | - |
dc.subject.local | macrophage | - |
dc.subject.local | Macrophages | - |
dc.subject.local | Macrophage | - |
dc.subject.local | P38 | - |
dc.subject.local | p38 | - |
dc.subject.local | PTK | - |
dc.description.journalClass | Y | - |
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