DC Field | Value | Language |
---|---|---|
dc.contributor.author | Michael O Agaphonov | - |
dc.contributor.author | Anna N Packeiser | - |
dc.contributor.author | Maria B Chechenova | - |
dc.contributor.author | Eui Sung Choi | - |
dc.contributor.author | Michael D Ter-Avanesyan | - |
dc.date.accessioned | 2017-04-19T08:57:42Z | - |
dc.date.available | 2017-04-19T08:57:42Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0749-503X | - |
dc.identifier.uri | 10.1002/yea.678 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5352 | - |
dc.description.abstract | A Hansenula polymorpha mutant with enhanced ability to secrete a heterologous protein has been isolated. The mutation defines a gene, designated OPU24, which encodes a protein highly homologous to GDP-mannose pyrophosphorylase Psa1p/Srb1p/Vig9p of Saccharomyces cerevisiae and CaSrb1p of Candida albicans. The opu24 mutant manifests phenotypes similar to those of S. cerevisiae mutants depleted for GDP-mannose, such as cell wall fragility and defects in N- and O-glycosylation of secreted proteins. The influence of the opu24 mutation on endoplasmic reticulum-associated protein degradation is discussed. The GenBank Accession No. for the OPU24 sequence is AF234177. | - |
dc.publisher | Wiley | - |
dc.title | Mutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha | - |
dc.title.alternative | Mutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha | - |
dc.type | Article | - |
dc.citation.title | Yeast | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 402 | - |
dc.citation.startPage | 391 | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Eui Sung Choi | - |
dc.contributor.alternativeName | Agaphonov | - |
dc.contributor.alternativeName | Packeiser | - |
dc.contributor.alternativeName | Chechenova | - |
dc.contributor.alternativeName | 최의성 | - |
dc.contributor.alternativeName | Ter-Avanesyan | - |
dc.identifier.bibliographicCitation | Yeast, vol. 18, no. 5, pp. 391-402 | - |
dc.identifier.doi | 10.1002/yea.678 | - |
dc.subject.keyword | cell wall | - |
dc.subject.keyword | hansenula polymorpha | - |
dc.subject.keyword | protein glycosylation | - |
dc.subject.keyword | protein secretion | - |
dc.subject.keyword | urinary type plasminogen activator | - |
dc.subject.keyword | yeast | - |
dc.subject.local | cell wall | - |
dc.subject.local | Cell wall | - |
dc.subject.local | Hansenulapolymorpha | - |
dc.subject.local | hansenula polymorpha | - |
dc.subject.local | Hansenula polymorpha | - |
dc.subject.local | Hansenula polymorpha (Pichia angusta) | - |
dc.subject.local | protein glycosylation | - |
dc.subject.local | Protein glycosylation | - |
dc.subject.local | Protein secretion | - |
dc.subject.local | protein secretion | - |
dc.subject.local | urinary type plasminogen activator | - |
dc.subject.local | Yeast | - |
dc.subject.local | yeasts | - |
dc.subject.local | yeast | - |
dc.description.journalClass | Y | - |
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