Mutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha

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dc.contributor.authorMichael O Agaphonov-
dc.contributor.authorAnna N Packeiser-
dc.contributor.authorMaria B Chechenova-
dc.contributor.authorEui Sung Choi-
dc.contributor.authorMichael D Ter-Avanesyan-
dc.date.accessioned2017-04-19T08:57:42Z-
dc.date.available2017-04-19T08:57:42Z-
dc.date.issued2001-
dc.identifier.issn0749-503X-
dc.identifier.uri10.1002/yea.678ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5352-
dc.description.abstractA Hansenula polymorpha mutant with enhanced ability to secrete a heterologous protein has been isolated. The mutation defines a gene, designated OPU24, which encodes a protein highly homologous to GDP-mannose pyrophosphorylase Psa1p/Srb1p/Vig9p of Saccharomyces cerevisiae and CaSrb1p of Candida albicans. The opu24 mutant manifests phenotypes similar to those of S. cerevisiae mutants depleted for GDP-mannose, such as cell wall fragility and defects in N- and O-glycosylation of secreted proteins. The influence of the opu24 mutation on endoplasmic reticulum-associated protein degradation is discussed. The GenBank Accession No. for the OPU24 sequence is AF234177.-
dc.publisherWiley-
dc.titleMutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha-
dc.title.alternativeMutation of the homologue of GDP-mannose pyrophosphorylase alters cell wall structure, protein glycosylation and secretion in Hansenula polymorpha-
dc.typeArticle-
dc.citation.titleYeast-
dc.citation.number5-
dc.citation.endPage402-
dc.citation.startPage391-
dc.citation.volume18-
dc.contributor.affiliatedAuthorEui Sung Choi-
dc.contributor.alternativeNameAgaphonov-
dc.contributor.alternativeNamePackeiser-
dc.contributor.alternativeNameChechenova-
dc.contributor.alternativeName최의성-
dc.contributor.alternativeNameTer-Avanesyan-
dc.identifier.bibliographicCitationYeast, vol. 18, no. 5, pp. 391-402-
dc.identifier.doi10.1002/yea.678-
dc.subject.keywordcell wall-
dc.subject.keywordhansenula polymorpha-
dc.subject.keywordprotein glycosylation-
dc.subject.keywordprotein secretion-
dc.subject.keywordurinary type plasminogen activator-
dc.subject.keywordyeast-
dc.subject.localcell wall-
dc.subject.localCell wall-
dc.subject.localHansenulapolymorpha-
dc.subject.localhansenula polymorpha-
dc.subject.localHansenula polymorpha-
dc.subject.localHansenula polymorpha (Pichia angusta)-
dc.subject.localprotein glycosylation-
dc.subject.localProtein glycosylation-
dc.subject.localProtein secretion-
dc.subject.localprotein secretion-
dc.subject.localurinary type plasminogen activator-
dc.subject.localYeast-
dc.subject.localyeasts-
dc.subject.localyeast-
dc.description.journalClassY-
Appears in Collections:
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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