Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease

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Title
Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease
Author(s)
Byung Sun Min; Hyun Ju Jung; Jun Sung Lee; Young Ho Kim; Song Hae Bok; Chao Mei Ma; Norio Nakamura; Masao Hattori; Ki Hwan Bae
Bibliographic Citation
Planta Medica, vol. 65, no. 4, pp. 374-375
Publication Year
1999
Abstract
The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 μg/ml. The subsequent fractionation and isolation of the extract gave two active corn pounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV 1 protease with IC50 values of 5.5 and 8.0 μM, respectively.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2006-960792
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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