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- Title
- Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease
- Author(s)
- Byung Sun Min; Hyun Ju Jung; Jun Sung Lee; Young Ho Kim; Song Hae Bok; Chao Mei Ma; Norio Nakamura; Masao Hattori; Ki Hwan Bae
- Bibliographic Citation
- Planta Medica, vol. 65, no. 4, pp. 374-375
- Publication Year
- 1999
- Abstract
- The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 μg/ml. The subsequent fractionation and isolation of the extract gave two active corn pounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV 1 protease with IC50 values of 5.5 and 8.0 μM, respectively.
- ISSN
- 0032-0943
- Publisher
- Georg Thieme Verlag Kg
- DOI
- http://dx.doi.org/10.1055/s-2006-960792
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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