Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression

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dc.contributor.authorGoo Taeg Oh-
dc.contributor.authorJae Hoon Choi-
dc.contributor.authorJung Joo Hong-
dc.contributor.authorDae Young Kim-
dc.contributor.authorSae Bom Lee-
dc.contributor.authorJu Ryoung Kim-
dc.contributor.authorChul Ho Lee-
dc.contributor.authorByung Hwa Hyun-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorSong Hae Bok-
dc.contributor.authorTae Sook Jeong-
dc.date.accessioned2017-04-19T08:57:47Z-
dc.date.available2017-04-19T08:57:47Z-
dc.date.issued2001-
dc.identifier.issn0021-9150-
dc.identifier.uri10.1016/S0021-9150(01)00464-6ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5390-
dc.description.abstractHematein is a compound isolated from Caesalpinia sappan that has been used in oriental medicine as both an analgesic and an anti-inflammatory agent. In this study, we examined the anti-atherogenic potential of hematein using cholesterol-fed New Zealand White (NZW) rabbits. NZW rabbits were divided into a hematein-supplemented (0.05% in diet) group (n = 6), a probucol-supplemented (0.25% in diet) group (n = 6), and a control group (n = 6). After 8 weeks of treatments, the extent of the atherosclerotic lesions was significantly reduced in the hematein-supplemented group and the probucol-supplemented group without changing plasma lipoprotein levels. Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet. In culture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of monocyte chemotactic protein-1 (MCP-1) respectively induced by tumor necrotic factor α (TNF-α) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell (HUVEC) culture. Also, hematein inhibited monocyte adhesion to endothelial cell and the activation of NF-κB in HUVECs stimulated with TNF-α. The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit.-
dc.publisherElsevier-
dc.titleDietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression-
dc.title.alternativeDietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression-
dc.typeArticle-
dc.citation.titleAtherosclerosis-
dc.citation.number1-
dc.citation.endPage26-
dc.citation.startPage17-
dc.citation.volume159-
dc.contributor.affiliatedAuthorGoo Taeg Oh-
dc.contributor.affiliatedAuthorJung Joo Hong-
dc.contributor.affiliatedAuthorSae Bom Lee-
dc.contributor.affiliatedAuthorJu Ryoung Kim-
dc.contributor.affiliatedAuthorChul Ho Lee-
dc.contributor.affiliatedAuthorByung Hwa Hyun-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorSong Hae Bok-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName오구택-
dc.contributor.alternativeName최재훈-
dc.contributor.alternativeName홍정주-
dc.contributor.alternativeName김대영-
dc.contributor.alternativeName이새봄-
dc.contributor.alternativeName김주령-
dc.contributor.alternativeName이철호-
dc.contributor.alternativeName현병화-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName복성해-
dc.contributor.alternativeName정태숙-
dc.identifier.bibliographicCitationAtherosclerosis, vol. 159, no. 1, pp. 17-26-
dc.identifier.doi10.1016/S0021-9150(01)00464-6-
dc.subject.keywordhematein-
dc.subject.keywordatherosclerosis-
dc.subject.keywordMCP-1-
dc.subject.keywordVCAM-1-
dc.subject.localHematein-
dc.subject.localhematein-
dc.subject.localatherosclerosis-
dc.subject.localAtherosclerosis-
dc.subject.localatheroclerosis-
dc.subject.localMCP-1-
dc.subject.localVCAM-1-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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