DC Field | Value | Language |
---|---|---|
dc.contributor.author | Goo Taeg Oh | - |
dc.contributor.author | Jae Hoon Choi | - |
dc.contributor.author | Jung Joo Hong | - |
dc.contributor.author | Dae Young Kim | - |
dc.contributor.author | Sae Bom Lee | - |
dc.contributor.author | Ju Ryoung Kim | - |
dc.contributor.author | Chul Ho Lee | - |
dc.contributor.author | Byung Hwa Hyun | - |
dc.contributor.author | Sei Ryang Oh | - |
dc.contributor.author | Song Hae Bok | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.date.accessioned | 2017-04-19T08:57:47Z | - |
dc.date.available | 2017-04-19T08:57:47Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | 10.1016/S0021-9150(01)00464-6 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5390 | - |
dc.description.abstract | Hematein is a compound isolated from Caesalpinia sappan that has been used in oriental medicine as both an analgesic and an anti-inflammatory agent. In this study, we examined the anti-atherogenic potential of hematein using cholesterol-fed New Zealand White (NZW) rabbits. NZW rabbits were divided into a hematein-supplemented (0.05% in diet) group (n = 6), a probucol-supplemented (0.25% in diet) group (n = 6), and a control group (n = 6). After 8 weeks of treatments, the extent of the atherosclerotic lesions was significantly reduced in the hematein-supplemented group and the probucol-supplemented group without changing plasma lipoprotein levels. Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet. In culture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of monocyte chemotactic protein-1 (MCP-1) respectively induced by tumor necrotic factor α (TNF-α) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell (HUVEC) culture. Also, hematein inhibited monocyte adhesion to endothelial cell and the activation of NF-κB in HUVECs stimulated with TNF-α. The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit. | - |
dc.publisher | Elsevier | - |
dc.title | Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression | - |
dc.title.alternative | Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression | - |
dc.type | Article | - |
dc.citation.title | Atherosclerosis | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 26 | - |
dc.citation.startPage | 17 | - |
dc.citation.volume | 159 | - |
dc.contributor.affiliatedAuthor | Goo Taeg Oh | - |
dc.contributor.affiliatedAuthor | Jung Joo Hong | - |
dc.contributor.affiliatedAuthor | Sae Bom Lee | - |
dc.contributor.affiliatedAuthor | Ju Ryoung Kim | - |
dc.contributor.affiliatedAuthor | Chul Ho Lee | - |
dc.contributor.affiliatedAuthor | Byung Hwa Hyun | - |
dc.contributor.affiliatedAuthor | Sei Ryang Oh | - |
dc.contributor.affiliatedAuthor | Song Hae Bok | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 오구택 | - |
dc.contributor.alternativeName | 최재훈 | - |
dc.contributor.alternativeName | 홍정주 | - |
dc.contributor.alternativeName | 김대영 | - |
dc.contributor.alternativeName | 이새봄 | - |
dc.contributor.alternativeName | 김주령 | - |
dc.contributor.alternativeName | 이철호 | - |
dc.contributor.alternativeName | 현병화 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 복성해 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.identifier.bibliographicCitation | Atherosclerosis, vol. 159, no. 1, pp. 17-26 | - |
dc.identifier.doi | 10.1016/S0021-9150(01)00464-6 | - |
dc.subject.keyword | hematein | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | MCP-1 | - |
dc.subject.keyword | VCAM-1 | - |
dc.subject.local | Hematein | - |
dc.subject.local | hematein | - |
dc.subject.local | atherosclerosis | - |
dc.subject.local | Atherosclerosis | - |
dc.subject.local | atheroclerosis | - |
dc.subject.local | MCP-1 | - |
dc.subject.local | VCAM-1 | - |
dc.description.journalClass | Y | - |
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