Hematein inhibits tumor necrotic factor-α-induced vascular cell adhesion molecule-1 and nuclear factor-κB dependent gene expression in human vascular endothelial cells

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dc.contributor.authorJung Joo Hong-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorJae Hoon Choi-
dc.contributor.authorJae Hak Park-
dc.contributor.authorKun Young Lee-
dc.contributor.authorYun Jeong Seo-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorGoo Taeg Oh-
dc.date.accessioned2017-04-19T08:57:47Z-
dc.date.available2017-04-19T08:57:47Z-
dc.date.issued2001-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1006/bbrc.2001.4480ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5391-
dc.description.abstractMonocyte adhesion to the endothelium via adhesion molecules is one of the earliest events in atherogenesis. It has been suggested that vascular cell adhesion molecule-1 (VCAM-1) plays a very important role in the recruitment of monocytes in atherosclerosis. The aim of our study was to evaluate whether hematein can influence the expression of VCAM-1 and the transcription of nuclear factor-κB (NF-κB)-dependent genes. Immunohistochemistry revealed that mouse aortic artery endothelial cells express VCAM-1 after feeding a high cholesterol diet for 8 weeks. Hematein dose dependently suppressed TNF-α-induced VCAM-1 in both surface (30.8%) and soluble protein (65%) production in HUVECs. The transcription level of VCAM-1 was measured by Northern blot analysis, and decreased VCAM-1 protein expression was associated with a reduction of VCAM-1 mRNA expression. Transient transfection study of NF-κB promoter construct and electrophoretic mobility shift assay suggested that hematein inhibited both NF-κB-dependent gene expression and NF-κB activation induced by TNF-α. Our results suggest that the down-regulation of VCAM-1 expression by hematein may in part be due to the inhibition of NF-κB-dependent gene expression.-
dc.publisherElsevier-
dc.titleHematein inhibits tumor necrotic factor-α-induced vascular cell adhesion molecule-1 and nuclear factor-κB dependent gene expression in human vascular endothelial cells-
dc.title.alternativeHematein inhibits tumor necrotic factor-α-induced vascular cell adhesion molecule-1 and nuclear factor-κB dependent gene expression in human vascular endothelial cells-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number5-
dc.citation.endPage1133-
dc.citation.startPage1127-
dc.citation.volume281-
dc.contributor.affiliatedAuthorJung Joo Hong-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorJae Hoon Choi-
dc.contributor.affiliatedAuthorKun Young Lee-
dc.contributor.affiliatedAuthorYun Jeong Seo-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorGoo Taeg Oh-
dc.contributor.alternativeName홍정주-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName최재훈-
dc.contributor.alternativeName박재학-
dc.contributor.alternativeName이건영-
dc.contributor.alternativeName서윤정-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName오구택-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 281, no. 5, pp. 1127-1133-
dc.identifier.doi10.1006/bbrc.2001.4480-
dc.subject.keywordendothelial cells-
dc.subject.keywordhematein-
dc.subject.keywordvascular cell adhesion molecule-
dc.subject.localEndothelial cell-
dc.subject.localendothelial cells-
dc.subject.localendothelial cell-
dc.subject.localEndothelial cells-
dc.subject.localHematein-
dc.subject.localhematein-
dc.subject.localvascular cell adhesion molecule-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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